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Prevalence
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Author | Year | Age | Population | Etiology | Study Type | More Study Information | Screened | Country | Prevalence | Standardization |
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Risk Factors for the Development of Posttraumatic Hydrocephalus After Unilateral Decompressive Craniectomy in Patients With Traumatic Brain Injury | Tsung-Ming Su, Chu-Mei Lan, Tsung-Han Lee, Shih-Wei Hsu, Nai-Wen Tsai, Cheng-Hsien Lu | 2019 | Adult | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Prospective | Retrospectively reviewed the medical records on 217 patients with moderate or severe TBI who had Glasgow Coma Scale (GCS) score of less than 13 on admission and underwent unilateral DC from 2008 to 2014. 143 patients with moderate or severe TBI were enrolled to determine the risk factors for the development of PTH before cranioplasty. | 143 patients | Taiwan | 30.1% developed posttraumatic hydrocephalus following decompressive craniectomy | 301/1,000 decompressive craniectomy following TBI |
Incidence of Hydrocephalus in Traumatic Brain Injury: A Nationwide Population-Based Cohort Study | Kai-Hua Chen, Chuan-Pin Lee, Yao-Hsu Yang, Yun-Hsuan Yang, Chien-Min Chen, Mong-Liang Lu, Yi-Chen Lee, Vincent Chin-Hung Chen | 2019 | All | Traumatic Brain Injury with SAH | Posttraumatic Hydrocephalus | Retrospective | In this population-based study, patients who had a first event of hospitalized TBI during 2000 to 2010 were identified from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. | 2,303 patients | Taiwan | 20.05/10,000 during 24-month follow-up period | 2.005/1,000 TBI cases with SAH during 24-month follow-up |
Incidence of Hydrocephalus in Traumatic Brain Injury: A Nationwide Population-Based Cohort Study | Kai-Hua Chen, Chuan-Pin Lee, Yao-Hsu Yang, Yun-Hsuan Yang, Chien-Min Chen, Mong-Liang Lu, Yi-Chen Lee, Vincent Chin-Hung Chen | 2019 | All | Traumatic Brain Injury w/o SAH | Posttraumatic Hydrocephalus | Retrospective | In this population-based study, patients who had a first event of hospitalized TBI during 2000 to 2010 were identified from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. | 21,472 patients | Taiwan | 5.28/10,000 during 24-month follow-up period | 0.528/1,000 TBI cases w/o SAH during 24-month follow-up |
Clinical Features of and Risk Factors for Hydrocephalus in Childhood Bacterial Meningitis | Liang Huo, Yuying Fan, Chunying Jiang, Jian Gao, Meng Yin, Hua Wang, Fenghua Yang, Qingjun Cao | 2019 | Child | Bacterial Meningitis | Post Infectious Hydrocephalus | Retrospective | Retrospectively reviewed the records of children aged <14 years who were treated for bacterial meningitis at the Shengjing Hospital of China Medical University between January 1, 2010, and December 31, 2016. | 267 patients | China | 9.4% developed post infectious hydrocephalus | 94/1,000 bacterial meningitis cases |
Prevalence of Idiopathic Normal Pressure Hydrocephalus: A Prospective, Population-Based Study | Johanna Andersson, Michelle Rosell, Karin Kockum, Otto Lilja-Lund, Lars Söderström, Katarina Laurell | 2019 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | Using the Swedish population register, 1,000 individuals from Jämtland, aged 65 years and older, were randomly selected and invited to participate in the study. | 673 inhabitants | Jämtland, Sweden | 3.7% had probable NPH (according to American-European guidelines); 1.5% had possible NPH w/ MRI support or definite NPH (according to Japanese guidelines) | 37/1,000 people (American-European Guidelines); 15/1,000 people (Japanese Guidelines) |
Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus | Okko T Pyykkö, Ossi Nerg, Hanna-Mari Niskasaari, Timo Niskasaari, Anne M Koivisto, Mikko Hiltunen, Jussi Pihlajamäki, Tuomas Rauramaa, Maria Kojoukhova, Irina Alafuzoff, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen | 2018 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Retrospective | The patients of the current study were recruited from a defined geographic area in Middle and Eastern Finland, of which the sole serving acute and elective neurosurgical unit is the department of neurosurgery of the Kuopio University Hospital (KUH). A cohort of 536 patients with possible NPH from a defined population with a median follow-up time of 5.1 years, (range 0.04–19.9 years) was included in the study. | catchement population of KUH Neurosurgery | Finland | 1.84/100,000 (range 0.8-4.5 per 100,000 per year) | .0184/1,000 |
The Incidence of Hydrocephalus and Shunting in Patients with Angiogram-Negative Subarachnoid Hemorrhage: An Updated Meta-Analysis | Sung-Eun Kim, Bong Jun Kim, Steve S Cho, Heung Cheol Kim, Jin Pyeong Jeon | 2018 | All | Angiogram-Negative Perimesencephalic Subarachnoid Hemorrhage | Post Hemorrhagic Hydrocephalus | Meta-Analysis | Electronic research studies were searched using the keywords “subarachnoid hemorrhage,” “SAH,” “perimesencephalic,” “angio-negative,” “hydrocephalus,” and “ventriculoperitoneal shunt” in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials in the Cochrane Library between January 1990 and November 2017. | 1159 patients | 9.7% developed post hemoorhagic hydrocephalus | 97/1,000 Angiogram-Negative Perimesencephalic SAH cases | |
The Incidence of Hydrocephalus and Shunting in Patients with Angiogram-Negative Subarachnoid Hemorrhage: An Updated Meta-Analysis | Sung-Eun Kim, Bong Jun Kim, Steve S Cho, Heung Cheol Kim, Jin Pyeong Jeon | 2018 | All | Angiogram-Negative Non-Perimesencephalic Subarachnoid Hemorrhage | Post Hemorrhagic Hydrocephalus | Meta-Analysis | Electronic research studies were searched using the keywords “subarachnoid hemorrhage,” “SAH,” “perimesencephalic,” “angio-negative,” “hydrocephalus,” and “ventriculoperitoneal shunt” in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials in the Cochrane Library between January 1990 and November 2017. | 1270 patients | 28.3% developed post hemorrhagic hydrocephalus | 283/1,000 Angiogram-Negative Non-Perimesencephalic SAH cases | |
Hydrocephalus in Pediatric Traumatic Brain Injury: National Incidence, Risk Factors, and Outcomes in 124,444 Hospitalized Patients | Kavelin Rumalla, Vijay Letchuman, Kyle A Smith, Paul M Arnold | 2018 | Child | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | Data from the KID, from 2003 to 2012, were used in this analysis. The KID is a part of the Healthcare Cost and Utilization Project (HCUP), maintained by the Agency for Healthcare Research and Quality (AHRQ). | 124,444 patients | United States | 1% developed posttraumatic hydrocephalus | 10/1,000 TBI cases |
Effect of Choice of Treatment Modality on the Incidence of Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage | Masaomi Koyanagi, Hitoshi Fukuda, Masaaki Saiki, Yoshihito Tsuji, Benjamin Lo, Toshinari Kawasaki, Yoshihiko Ioroi, Ryu Fukumitsu, Ryota Ishibashi, Masashi Oda, Osamu Narumi, Masaki Chin, Sen Yamagata, Susumu Miyamoto | 2018 | Adult | Subarachnoid Hemorrhage | Post Hemorrhagic Hydrocephalus | Prospective | Between January 2009 and July 2016, patients who underwent surgical clipping and endovascular treatment for ruptured cerebral aneurysms within 72 hours after onset were entered into a prospectively maintained multicenter SAH database comprising 3 Japanese stroke centers. | 566 patients | Japan | 22% developed post hemorrhaigc hydrocephalus | 220/1,000 SAH cases |
Prevalence and Trend of Isolated and Complicated Congenital Hydrocephalus and Preventive Effect of Folic Acid in Northern China, 2005-2015 | Jufen Liu, Lei Jin, Zhiwen Li, Yali Zhang, Le Zhang, Linlin Wang, Aiguo Ren | 2018 | Neonate | Neonate w/ Birth Defects | Congenital Hydrocephalus | Retrospective | A population–based birth defects surveillance program was set up in the study population in the early 2000s.The present study included data from five rural counties, namely, Pingding, Xiyang, Taigu, Zezhou and Shouyang (Shanxi Province), from 2005 to 2015. | 176,223 births | Northern China | 20.3/10,000 births | 2.03/1,000 births |
Prevalence and Trend of Isolated and Complicated Congenital Hydrocephalus and Preventive Effect of Folic Acid in Northern China, 2005-2015 | Jufen Liu, Lei Jin, Zhiwen Li, Yali Zhang, Le Zhang, Linlin Wang, Aiguo Ren | 2018 | Neonate | Neonate w/ Birth Defects | Isolated Congenital Hydrocephalus | Retrospective | A population–based birth defects surveillance program was set up in the study population in the early 2000s.The present study included data from five rural counties, namely, Pingding, Xiyang, Taigu, Zezhou and Shouyang (Shanxi Province), from 2005 to 2015. | 176,223 births | Northern China | 8.3/10,000 births | 0.83/1,000 births |
Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance | Albert M Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G Hamilton | 2018 | All | All | All Hydrocephalus | Meta-Analysis | Data on the prevalence of hydrocephalus were obtained through a systematic review and metanalysis of published peer-reviewed population-based articles specific to the epidemiology of hydrocephalus. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. | 171,558,651 people | Global | 84.7/100,000 | 0.847/1,000 |
Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance | Albert M Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G Hamilton | 2018 | Child | Child | All Hydrocephalus | Meta-Analysis | Data on the prevalence of hydrocephalus were obtained through a systematic review and metanalysis of published peer-reviewed population-based articles specific to the epidemiology of hydrocephalus. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. | 28,990,298 people | Global | 87.8/100,000 | 0.878/1,000 |
Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance | Albert M Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G Hamilton | 2018 | Adult | Adult | All Hydrocephalus | Meta-Analysis | Data on the prevalence of hydrocephalus were obtained through a systematic review and metanalysis of published peer-reviewed population-based articles specific to the epidemiology of hydrocephalus. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Adults aged 19-64. | 14,798,172 people | Global | 10.9/100,000 | 0.109/1,000 |
Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance | Albert M Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G Hamilton | 2018 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Meta-Analysis | Data on the prevalence of hydrocephalus were obtained through a systematic review and metanalysis of published peer-reviewed population-based articles specific to the epidemiology of hydrocephalus. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Adults 65+. | 127,770,181 people | Global | 174.8/100,000 | 1.748/1,000 |
Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance | Albert M Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G Hamilton | 2018 | Neonate | Neonate | Congenital Hydrocephalus | Meta-Analysis | Data on the incidence of hydrocephalus was obtained from the ICBDSR’s annual reports. The ICBDSR is a non-governmental organization affiliated with the World Health Organization that collects data on birth defects including hydrocephalus and spina bifida from 42 surveillance programs, spanning 36 countries. Annual reports from 2003-2014 were reviewed. | 42 ICBDSR surveillance registries | 36 countries | 81.2/100,000 | .812/1,000 |
Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance | Albert M Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G Hamilton | 2018 | Neonate | Neonate | Isolated Congenital Hydrocephalus | Meta-Analysis | Data on the incidence of hydrocephalus was obtained from the ICBDSR’s annual reports. The ICBDSR is a non-governmental organization affiliated with the World Health Organization that collects data on birth defects including hydrocephalus and spina bifida from 42 surveillance programs, spanning 36 countries. Annual reports from 2003-2014 were reviewed. | 42 ICBDSR surveillance registries | 36 countries | 49.5/100,000 | .495/1,000 |
Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis | Michael C Dewan, Abbas Rattani, Rania Mekary, Laurence J Glancz, Ismaeel Yunusa, Ronnie E Baticulon, Graham Fieggen, John C Wellons, Kee B Park, Benjamin C Warf | 2018 | Neonate | Neonate | Congenital Hydrocephalus | Meta-Analysis | The authors performed a systematic literature review and meta-analysis to estimate the incidence of congenital hydrocephalus by WHO region and World Bank income level using the MEDLINE/PubMed and Cochrane Database of Systematic Reviews databases. A global estimate of pediatric hydrocephalus was obtained by adding acquired forms of childhood hydrocephalus to the baseline congenital figures using neural tube defect (NTD) registry data and known proportions of posthemorrhagic and postinfectious cases. | 78 articles reviewed | Africa | 145/100,000 births | 1.45/1,000 births |
Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis | Michael C Dewan, Abbas Rattani, Rania Mekary, Laurence J Glancz, Ismaeel Yunusa, Ronnie E Baticulon, Graham Fieggen, John C Wellons, Kee B Park, Benjamin C Warf | 2018 | Neonate | Neonate | Congenital Hydrocephalus | Meta-Analysis | The authors performed a systematic literature review and meta-analysis to estimate the incidence of congenital hydrocephalus by WHO region and World Bank income level using the MEDLINE/PubMed and Cochrane Database of Systematic Reviews databases. A global estimate of pediatric hydrocephalus was obtained by adding acquired forms of childhood hydrocephalus to the baseline congenital figures using neural tube defect (NTD) registry data and known proportions of posthemorrhagic and postinfectious cases. | 78 articles reviewed | Latin America | 316/100,000 births | 3.16/1,000 births |
Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis | Michael C Dewan, Abbas Rattani, Rania Mekary, Laurence J Glancz, Ismaeel Yunusa, Ronnie E Baticulon, Graham Fieggen, John C Wellons, Kee B Park, Benjamin C Warf | 2018 | Neonate | Neonate | Congenital Hydrocephalus | Meta-Analysis | The authors performed a systematic literature review and meta-analysis to estimate the incidence of congenital hydrocephalus by WHO region and World Bank income level using the MEDLINE/PubMed and Cochrane Database of Systematic Reviews databases. A global estimate of pediatric hydrocephalus was obtained by adding acquired forms of childhood hydrocephalus to the baseline congenital figures using neural tube defect (NTD) registry data and known proportions of posthemorrhagic and postinfectious cases. | 78 articles reviewed | United States/Canada | 68/100,000 births | 0.68/10,000 births |
Posttraumatic Hydrocephalus as a Confounding Influence on Brain Injury Rehabilitation: Incidence, Clinical Characteristics, and Outcomes | Alan H Weintraub, Donald J Gerber, Robert G Kowalski | 2017 | All | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | All patients admitted to our inpatient brain injury rehabilitation hospital for TBI from 2009 to 2013 were evaluated for PTH. | 701 patients | Colorado, United States | 8% were diagnosed with posttraumatic hydrocephalus | 80/1,000 TBI cases |
Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study | Junyan Qu, Taoyou Zhou, Cejun Zhong, Rong Deng & Xiaoju Lü | 2017 | All | Cryptococcal Meningitis | Post Infectious Hydrocephalus | Retrospective | The retrospective study was conducted between January 2008 and December 2015, in West China Hospital, Sichuan University, China (a 4,300-bed academic tertiary care hospital). Patients aged 14 years or older with confirmed diagnosis of CM or clinical or confirmed diagnosis of TBM were included. | 126 patients | China | 12.7% developed post infectious hydrocephalus | 127/1,000 cryptococcal meningitis |
Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study | Junyan Qu, Taoyou Zhou, Cejun Zhong, Rong Deng & Xiaoju Lü | 2017 | All | Tuberculous Meningitis | Post Infectious Hydrocephalus | Retrospective | The retrospective study was conducted between January 2008 and December 2015, in West China Hospital, Sichuan University, China (a 4,300-bed academic tertiary care hospital). Patients aged 14 years or older with confirmed diagnosis of CM or clinical or confirmed diagnosis of TBM were included. | 105 patients | China | 16.2% developed post infectious hydrocephalus | 162/1,000 tuberculous meningitis cases |
Changes in Prevalence and Perinatal Outcomes of Congenital Hydrocephalus Among Chinese Newborns: A Retrospective Analysis Based on the Hospital-Based Birth Defects Surveillance System | Ling Yi, Chaomin Wan, Changfei Deng, Xiaohong Li, Kui Deng, Yi Mu, Jun Zhu, Qi Li, Yanping Wang, Li Dai | 2017 | Neonate | Neonate w/ Birth Defects | Congenital Hydrocephalus | Retrospective | Data were obtained from the Chinese Birth Defects Monitoring Network (CBDMN), which collects demographic information on all newborns above 28 weeks of gestation, and clinical information on neonates with congenital anomalies. CH cases delivered during 2005–2012 were analyzed. | 10,574,061 births | China | 6.14/10,000 births | 0.614/1,000 births |
Nationwide hospital‐based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics | Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Urae, and Hajime Arai | 2017 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | This study consisted of two epidemiological surveys. First, the total number of patients with a diagnosis of iNPH who received medical care during the year 2012 was estimated. Then, in the second survey to clarify the clinical features of this disease, the attending physicians of all patients registered in the first survey were asked to answer a questionnaire regarding specific clinical information and to mail it back. | Japan’s population (sample from select hospitals) | Japan | 10.2/100,000 people | 0.102/1,000 people |
Paradoxical reaction in tuberculous meningitis: presentation, predictors and impact on prognosis | Anurag Kumar Singh, Hardeep Singh Malhotra, Ravindra Kumar Garg, Amita Jain, Neeraj Kumar, Neera Kohli, Rajesh Verma, Praveen Kumar Sharma | 2016 | Adult | Tuberculous Meningitis | Post Infectious Hydrocephalus | Prospective | All consecutive newly-diagnosed patients of tuberculous meningitis, fulfilling the consensus diagnostic criteria as described by Marais et al., were included. Patients were categorized into definite, probable, or possible tuberculous meningitis groups on the basis of clinical, imaging, and laboratory criteria. | 141 patients | India | 19% developed post infectious hydrocephalus | 190/1,000 tuberculous meningitis cases |
Incidence of Idiopathic Normal-Pressure Hydrocephalus in Northern Spain | Rubén Martín-Láez, Hugo Caballero-Arzapalo, Natalia Valle-San Román, Luis Ángel López-Menéndez, Juan Carlos Arango-Lasprilla, Alfonso Vázquez-Barquero | 2016 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | Cantabria is a small, autonomous community in northern Spain that is served by only 1 neurosurgical department. On January 1, 2013, our reference population consisted of 591,888 inhabitants served by 3 departments of neurology and the entire primary care network of Cantabria. Owing to the special characteristics of the Spanish Health System, referral of patients to other neurosurgical departments is rare, if possible at all. | Population of Cantabria, Spain | Cantabria, Spain | 3.25 cases per 100,000 inhabitants per year | .0325 cases/1,000 inhabitants/year |
Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000–2010 | Eisha A Christian, Diana L Jin, Frank Attenello, Timothy Wen, Steven Cen, William J Mack, Mark D Krieger, J Gordon McComb | 2016 | Neonate | Preterm neonates w/ Grade 1 IVH | Post Hemorrhagic Hydrocephalus | Retrospective | The NIS and KID together compose the largest, public, all-payer, inpatient care dataset in the United States (https://www.hcup-us.ahrq.gov/databases.jsp). As part of the Healthcare Cost and Utilization Project (HCUP), the NIS and KID have longitudinal hospital inpatient discharge data from more than 1000 hospitals, with the NIS representing 20% of all hospital discharges and KID representing 80% of pediatric discharges in the United States. | 549 patients | United States | 1% developed post hemorrhagic hydrocephalus | 10/1,000 preterm infants with IVH grade 1 cases |
Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000–2010 | Eisha A Christian, Diana L Jin, Frank Attenello, Timothy Wen, Steven Cen, William J Mack, Mark D Krieger, J Gordon McComb | 2016 | Neonate | Preterm neonates w/ Grade 2 IVH | Post Hemorrhagic Hydrocephalus | Retrospective | The NIS and KID together compose the largest, public, all-payer, inpatient care dataset in the United States (https://www.hcup-us.ahrq.gov/databases.jsp). As part of the Healthcare Cost and Utilization Project (HCUP), the NIS and KID have longitudinal hospital inpatient discharge data from more than 1000 hospitals, with the NIS representing 20% of all hospital discharges and KID representing 80% of pediatric discharges in the United States. | 1,127 patients | United States | 4% developed post hemorrhagic hydrocephalus | 40/1,000 preterm infants with IVH grade 2 cases |
Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000–2010 | Eisha A Christian, Diana L Jin, Frank Attenello, Timothy Wen, Steven Cen, William J Mack, Mark D Krieger, J Gordon McComb | 2016 | Neonate | Preterm neonates w/ Grade 3 IVH | Post Hemorrhagic Hydrocephalus | Retrospective | The NIS and KID together compose the largest, public, all-payer, inpatient care dataset in the United States (https://www.hcup-us.ahrq.gov/databases.jsp). As part of the Healthcare Cost and Utilization Project (HCUP), the NIS and KID have longitudinal hospital inpatient discharge data from more than 1000 hospitals, with the NIS representing 20% of all hospital discharges and KID representing 80% of pediatric discharges in the United States. | 4,890 patients | United States | 25% developed post hemorrhagic hydrocephalus | 250/1,000 preterm infants with IVH grade 3 cases |
Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000–2010 | Eisha A Christian, Diana L Jin, Frank Attenello, Timothy Wen, Steven Cen, William J Mack, Mark D Krieger, J Gordon McComb | 2016 | Neonate | Preterm neonates w/ Grade 4 IVH | Post Hemorrhagic Hydrocephalus | Retrospective | The NIS and KID together compose the largest, public, all-payer, inpatient care dataset in the United States (https://www.hcup-us.ahrq.gov/databases.jsp). As part of the Healthcare Cost and Utilization Project (HCUP), the NIS and KID have longitudinal hospital inpatient discharge data from more than 1000 hospitals, with the NIS representing 20% of all hospital discharges and KID representing 80% of pediatric discharges in the United States. | 5,651 patients | United States | 28% developed post hemorrhagic hydrocephalus | 280/1,000 preterm infants with IVH grade 3 cases |
Epidemiology of Birth Defects Based on a Birth Defect Surveillance System From 2005 to 2014 in Hunan Province, China | Donghua Xie, Tubao Yang, Zhiyu Liu, Hua Wang | 2016 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | This study involved all the infants (including stillbirth, dead fetus or live birth) during perinatal period (between 28 weeks of gestation and 7 days after birth) born in the 52 registered hospitals of Hunan between 2005 and 2014. | 925,413 births | Hunan Province, China | 4.3-11.8/10,000 births | .43-1.19/1,000 births |
Intraventricular Hemorrhage and Post Hemorrhagic Hydrocephalus among Very-Low-Birth-Weight Infants in Korea | So Yoon Ahn, So-Yeon Shim, In Kyung Sung | 2015 | Neonate | VLBW Infants w/ IVH Grade 1 | Post Hemorrhagic Hydrocephalus | Prospective | We performed a cohort study using prospectively collected data from 55 Korean Neonatal Network (KNN) centers. A total of 2,386 VLBW infants born between January 2013 and June 2014 and registered in the KNN were reviewed. We excluded 63 VLBW infants who did not have documented brain ultrasonography (BUS) results, and among them, 60 infants were expired within 7 days after birth. Finally, the remaining 2,323 were included in the present study. | 554 patients | Korea | 0% developed PHH | 0/1,000 VLBW infant IVH grade 1 cases |
Intraventricular Hemorrhage and Post Hemorrhagic Hydrocephalus among Very-Low-Birth-Weight Infants in Korea | So Yoon Ahn, So-Yeon Shim, In Kyung Sung | 2015 | Neonate | VLBW Infants w/ IVH Grade 2 | Post Hemorrhagic Hydrocephalus | Prospective | We performed a cohort study using prospectively collected data from 55 Korean Neonatal Network (KNN) centers. A total of 2,386 VLBW infants born between January 2013 and June 2014 and registered in the KNN were reviewed. We excluded 63 VLBW infants who did not have documented brain ultrasonography (BUS) results, and among them, 60 infants were expired within 7 days after birth. Finally, the remaining 2,323 were included in the present study. | 144 patients | Korea | 3.5% developed PHH | 35/1,000 VLBW infant IVH grade 2 cases |
Intraventricular Hemorrhage and Post Hemorrhagic Hydrocephalus among Very-Low-Birth-Weight Infants in Korea | So Yoon Ahn, So-Yeon Shim, In Kyung Sung | 2015 | Neonate | VLBW Infants w/ IVH Grade 3 | Post Hemorrhagic Hydrocephalus | Prospective | We performed a cohort study using prospectively collected data from 55 Korean Neonatal Network (KNN) centers. A total of 2,386 VLBW infants born between January 2013 and June 2014 and registered in the KNN were reviewed. We excluded 63 VLBW infants who did not have documented brain ultrasonography (BUS) results, and among them, 60 infants were expired within 7 days after birth. Finally, the remaining 2,323 were included in the present study. | 83 patients | Korea | 36.1% developed PHH | 361/1,000 VLBW infant IVH grade 3 cases |
Intraventricular Hemorrhage and Post Hemorrhagic Hydrocephalus among Very-Low-Birth-Weight Infants in Korea | So Yoon Ahn, So-Yeon Shim, In Kyung Sung | 2015 | Neonate | VLBW Infants w/ IVH Grade 4 | Post Hemorrhagic Hydrocephalus | Prospective | We performed a cohort study using prospectively collected data from 55 Korean Neonatal Network (KNN) centers. A total of 2,386 VLBW infants born between January 2013 and June 2014 and registered in the KNN were reviewed. We excluded 63 VLBW infants who did not have documented brain ultrasonography (BUS) results, and among them, 60 infants were expired within 7 days after birth. Finally, the remaining 2,323 were included in the present study. | 47 patients | Korea | 63.8% developed PHH | 638/1,000 VLBW infant IVH grade 4 cases |
Temporal trends of intraventricular hemorrhage of prematurity in Nova Scotia from 1993 to 2012 | Julia A E Radic, Michael Vincer, P Daniel McNeely | 2015 | Neonate | Preterm neonates w/ Grade 1 IVH | Post Hemorrhagic Hydrocephalus | Prospective | All very preterm (≤ 30 completed weeks’ gestational age) infants born to residents of Nova Scotia from January 1, 1993, onward were included in a comprehensive database. | 170 patients | Nova Scotia, Canada | 0% developed post hemorrhagic hydrocephalus | 0/1,000 preterm infants with IVH grade 1 cases |
Temporal trends of intraventricular hemorrhage of prematurity in Nova Scotia from 1993 to 2012 | Julia A E Radic, Michael Vincer, P Daniel McNeely | 2015 | Neonate | Preterm neonates w/ Grade 2 IVH | Post Hemorrhagic Hydrocephalus | Prospective | All very preterm (≤ 30 completed weeks’ gestational age) infants born to residents of Nova Scotia from January 1, 1993, onward were included in a comprehensive database. | 88 patients | Nova Scotia, Canada | 0% developed post hemorrhagic hydrocephalus | 0/1,000 preterm infants with IVH grade 2 cases |
Temporal trends of intraventricular hemorrhage of prematurity in Nova Scotia from 1993 to 2012 | Julia A E Radic, Michael Vincer, P Daniel McNeely | 2015 | Neonate | Preterm neonates w/ Grade 3 IVH | Post Hemorrhagic Hydrocephalus | Prospective | All very preterm (≤ 30 completed weeks’ gestational age) infants born to residents of Nova Scotia from January 1, 1993, onward were included in a comprehensive database. | 62 patients | Nova Scotia, Canada | 24% developed post hemorrhagic hydrocephalus | 240/1,000 preterm infants with IVH grade 3 cases |
Temporal trends of intraventricular hemorrhage of prematurity in Nova Scotia from 1993 to 2012 | Julia A E Radic, Michael Vincer, P Daniel McNeely | 2015 | Neonate | Preterm neonates w/ Grade 4 IVH | Post Hemorrhagic Hydrocephalus | Prospective | All very preterm (≤ 30 completed weeks’ gestational age) infants born to residents of Nova Scotia from January 1, 1993, onward were included in a comprehensive database. | 87 patients | Nova Scotia, Canada | 37% developed post hemorrhagic hydrocephalus | 370/1,000 preterm infants with IVH grade 4 cases |
Incidence of idiopathic normal pressure hydrocephalus (iNPH): a 10-year follow-up study of a rural community in Japan. | Iseki C, Takahashi Y, Wada M, Kawanami T, Adachi M, Kato T. | 2014 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | Conducted a longitudinal study in a rural area of northern Japan in 2000. At that time, 350 inhabitants, the total population of 70-year-olds in Takahata (who were born in 1930) were requested to participate in the study. | 271 inhabitants of Takahata | Japan | 1.2/1000/year | 70+: 1.2/1,000/year |
Prevalence of idiopathic normal-pressure hydrocephalus. | Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelsø C. | 2014 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | Between 1986 and 2000, studies on representative elderly populations in Gothenburg, Sweden, were conducted using identical examinations (including neuropsychiatric examinations and key informant interviews) at each occasion. All participants were systematically obtained from the Swedish population register based on birth dates and included people living in private households and in residential care. Subsamples were examined with CT of the brain. CT scans made between 1986 and 2000 were available and used in this study. | 1,238 between 1986-2000 | Sweden | Age 70-79: 0.2% Age 80+: 5.9% | 70-79: 2/1,000 80+: 59/1,000 |
Hydrocephalus in tuberculous meningitis: Incidence, its predictive factors and impact on the prognosis. | Raut T, Garg RK, Jain A, Verma R, Singh MK, Malhotra HS, Kohli N, Parihar A. | 2013 | Adult | Tuberculous Meningitis | Post Infectious Hydrocephalus | Prospective | Prospective cohort study, conducted from October 2010 to august 2012, in the Department of Neurology, King George’s Medical University | 80 patients | Uttar Pradesh, India | 67% after tuberculous meningitis | 670/1,000 after tuberculosus meningitis |
Hydrocephalus following severe traumatic brain injury in adults. Incidence, timing, and clinical predictors during rehabilitation. | Kammersgaard LP, Linnemann M, Tibæk M. | 2013 | Adult | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Prospective | Prospectively followed all patients (n = 444) in Eastern Denmark (population 2.5 mill) sustaining severe TBI, who required lengthy rehabilitation between 2000 and 2010 | 444 patients | Eastern Denmark | 14.2% of severe TBI patients Prevalence in population 0.00252% | 140/1,000 of severe TBI patients Prevalence: population 0.0252/1,000 |
Incidence and Risk Factors for Post-Traumatic Hydrocephalus following Decompressive Craniectomy for Intractable Intracranial Hypertension and Evacuation of Mass Lesions |
Honeybul & Ho | 2013 | Adult | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | Patients who received a decompressive craniectomy at the two major trauma hospitals in Western Australia between 2004 and 2010 | 194 patients who had had a decompressive craniectomy for severe TBI between 2004 and 2010 | Australia | 36% developed hydrocephalus requiring VP shunt | 360/1,000 of severe TBI patients |
Epidemiology, natural history, progression, and postnatal outcome of severe fetal ventriculomegaly. | Hannon T, Tennant PW, Rankin J, Robson SC. | 2013 | Fetus | Fetus | Ventriculomegaly | Prospective | Data were obtained from the Northern Congenital Abnormality Survey for the period 1994-2008 | 441,247 eligible births | North of England | 3.6 severe/10,000 pregnancies, 64.3% of women terminated births | 0.36/1,000 pregnancies |
Incidence of hydrocephalus and the need to ventriculoperitoneal shunting in premature infants with intraventricular hemorrhage: risk factors and outcome. | Behjati S, Emami-Naeini P, Nejat F, El Khashab M. | 2011 | Neonate | Intraventricular Hemorrhage | Post Hemorrhagic Hydrocephalus | Retrospective | A historical cohort study was conducted, consisting of 97 premature infants in whom the diagnosis of IVH was previously made by cranial ultrasound and were referred to pediatric neurosurgery clinic and/or neonatal intensive care unit of Children’s Hospital Medical Center in Tehran, Iran, from April 2004 to March 2009. Among the patients, those who were followed up for at least 6 months after the diagnosis of IVH were included in the study | 97 premature infants with IVH | Tehran, Iran | 35% required VP shunt – all grade 3 or 4 IVH | 350/1,000 IVH preterm neonates required VP shunt |
Posttraumatic hydrocephalus associated with decompressive cranial defect in severe brain-injured patients. | Shi SS, Zhang GL, Zeng T, Lin YF | 2011 | Adult | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | Patients suffering from severe head trauma between January 2004 and May 2010 | 389 patients w/ severe head trauma; 149 underwent decompressive craniectomy |
Fuzhou, China | 16.8% of those who underwent DC; 9.6% of the remaining patients who did not undergo DC | 168/1,000 of severe TBI cases which underwent DC; 96/1000 of severe TBI cases w/o DC |
Prevalence, natural history, and clinical outcome of mild to moderate ventriculomegaly. | Sethna F, Tennant PW, Rankin J, C Robson S. | 2011 | Fetus | Fetus | Ventriculomegaly | Prospective | Data were extracted from the U.K. Northern Congenital Abnormality Survey for cases identified during 1994–2008 | 454,080 registered births | North of England | 7.8 mild to moderate/10,000 total | 0.78/1,000 registered births |
Prevalence of congenital hydrocephalus in California, 1991-2000. | Jeng S, Gupta N, Wrensch M, Zhao S, Wu YW. | 2011 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | Data extracted from the California Office of Statewide Health Planning and Development (OSHPD) discharge database for the period between 1991 and 2000 | 5,353,022 births | California, United States | 5.9/10,000 | 0.59/1,000 |
Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province, China. | Sun G, Xu ZM, Liang JF, Li L, Tang DX. | 2011 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | Assess prevalence by reviewing a database of all deliveries from 28 weeks up until 7 days of birth from January 1998 to December 2009 | 83,888 perinatal, 1998-2009 | Zhejiang Province, China | 0.92% of births | 9.2/1,000 births |
Incidence of intraventricular hemorrhage and post hemorrhagic hydrocephalus in preterm infants. | Sajjadian N, Fakhrai H, Jahadi R. | 2010 | Neonate | Neonate | Post Hemorrhagic Hydrocephalus | Prospective | Premature neonates (birth weight equal or less than 1500g and gestational age equal or less than 37 weeks) admitted to Mofid Hospital NICU during a one year period | 57 neonates 35 with hemorrhage 7 with PHH | Tehran, Iran | 12.3% of premature neonates 20% of preterm with hemorrhage – directly related to severity | 123/1,000 premature neonates 200/1,000 preterm with hemorrhage |
Congenital hydrocephalus–prevalence, prenatal diagnosis and outcome of pregnancy in four European regions. | Garne E, Loane M, Addor MC, Boyd PA, Barisic I, Dolk H. | 2010 | Neonate | Neonate w/ Birth Defects | Congenital Hydrocephalus | Retrospective | Data were taken from four European registries of congenital malformations (EUROCAT) for the tim period betwee 1996 and 2003. Cases with hydrocephalus associated wth neural tube defects not included. | 187,097 Registered neonates | Switzerland, UK, Denmark, Croatia | 4.65/10,000 48% terminated pregnancies | 0.465/1,000 |
Prevalence of possible idiopathic normal-pressure hydrocephalus in Japan: the Osaki-Tajiri project. | Tanaka N, Yamaguchi S, Ishikawa H, Ishii H, Meguro K. | 2009 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | Five hundred and sixty-seven participants were randomly selected from among the 1,654 members of the population aged 65 years and older in Tajiri, Japan | 567 participant randomly selected from population | Osaki-Tajiri, Japan | 1.40% 140/10,000 aged 65+ | 14.0/1,000 aged 65+ |
Five-year incidence of surgery for idiopathic normal pressure hydrocephalus in Norway. | Brean A, Fredø HL, Sollid S, Müller T, Sundstrøm T, Eide PK. | 2009 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Retrospective | Information about age, sex, operation year and operation type was collected retrospectively for all patients hospitalized from 2002 to 2006 with any diagnosis of iNPH and operated with insertion of a ventriculo-peritoneal or ventriculoatrial shunt system, or with endoscopic third ventriculostomy in any of Norway’s five regional neurosurgical centers. | 23.1M population 252 patients operated on | Vestfold county in Norway | 1.09/100,000/year incidence In >65: 30.2/100,000/5 years | 0.0109/1,000/year incidence In >65: 0.302/1,000/5 years |
Reynaldo Martinez (electronic signature) | Brean A, Eide PK. | 2008 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Prospective | In a stable population of 220,000 inhabitants, structured and intensive efforts were directed towards the public via local newspapers, radio and television channels, and directed towards the healthcare professionals via personal letters and lectures, to recruit patients with idiopathic NPH (iNPH) investigation during a 12-month period. This population is served by only one neurological department and one neurosurgical department, thus avoiding any leakage of patients during the investigation period. We determined those patients fulfilling the diagnostic criteria of probable iNPH. | 220,000 inhabitants | Norway | 21.9/100,000 5.5/100,000/year | 0.219/1,000 Incidence: 0.055/1,000/year |
Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community. | Hiraoka K, Meguro K, Mori E. | 2008 | Adult | Adult | Idiopathic Normal Pressure Hydrocephalus | Retrospective | The prevalence of idiopathic normal-pressure hydrocephalus (NPH) in a community was investigated by retrospective analysis of data from a previous community-based study of 170 randomly selected elderly residents aged 65 years or older. | 170 Randomly selected residents 65+ | Rural Japan | 2.90% | 29/1,000 age 65+ |
Risk factors related to hydrocephalus after traumatic subarachnoid hemorrhage. | Tian HL1, Xu T, Hu J, Cui YH, Chen H, Zhou LF. | 2008 | All | Subarachnoid Hemorrhage | Post Hemorrhagic Hydrocephalus | Prospective | A consecutive series of 370 patients with tSAH, defined as subarachnoid hemorrhagesecondary to head injury, were admitted at our institution from January 2002 to December 2004. Patients who had spontaneous subarachnoid hemorrhage with or without head injury were excluded. | 301 consecutive patients | China | 11.98% developed hydro | 119.8/1,000 |
Hydrocephalus in children born in 1999-2002: epidemiology, outcome and ophthalmological findings. | Persson EK, Anderson S, Wiklund LM, Uvebrant P | 2007 | Neonate | Neonate | Infantile hydrocephalus | Prospective | This prospective study was population-based, and the study area was the western part of Sweden during the birth year period 1999–2002 | 82,106 live born children From 1999-2002 | Sweden | 0.48/1,000 | 0.48/1,000 |
Outcomes after decompressive craniectomy for severe traumatic brain injury in children. | Kan P, Amini A, Hansen K, White GL Jr, Brockmeyer DL, Walker ML, Kestle JR | 2006 | Child | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | Reviewed the Trauma Registry at the Primary Children’s Medical Center to identify the cohort of children with severe TBI who underwent decompressive craniectomy between 1996 and 2005 | 35 surviving children/51 children with severe head trauma | Salt Lake City, Utah | 40% | 400/1,000 severe TBI cases |
Prevalence analysis on congenital hydrocephalus in Chinese perinatal from 1996 to 2004 | Dai L, Zhou GX, Miao L, Zhu J, Wang YP, Liang J | 2006 | Neonate | Neonate w/ Birth Defects | Congenital Hydrocephalus | Retrospective | Data gained from Chinese Birth Defects Monitoring Network from 1996 to 2004 | 4,282,536 births from 1996-2004 | China | 7.03/10,000 | 0.703/1,000 births |
Descriptive epidemiology of congenital hydrocephaly in Hawaii, 1986–2000. | Forrester MB, Merz RD | 2005 | Neonate | Neonate w/ Birth Defects | Congenital Hydrocephalus | Retrospective | Using data from a birth defects registry for the period between 1986 and 2000 | Hawaii | 10.4/10,000 live births | 1.04/1,000 live births | |
Hydrocephalus prevalence and outcome in a population-based cohort of children born in 1989-1998. | Persson EK, Hagberg G, Uvebrant P | 2005 | Neonate | Neonate | Infantile hydrocephalus | Retrospective | The study population was the 253 378 live births occurring in the western part of Sweden during the 10-y period 1989–1998. Information about birth characteristics as well as the aetiology of hydrocephalus and additional major impairments was obtained from rehabilitation centres and paediatric and neurosurgical records. | 253,378 Live born children from 1989-1998 | Sweden | 0.49/1,000 | 0.49/1,000 for infantile |
Hydrocephalus prevalence and outcome in a population-based cohort of children born in 1989-1998. | Persson EK, Hagberg G, Uvebrant P | 2005 | Neonate | Neonate | Myelomeningocoele | Retrospective | The study population was the 253 378 live births occurring in the western part of Sweden during the 10-y period 1989–1998. Information about birth characteristics as well as the aetiology of hydrocephalus and additional major impairments was obtained from rehabilitation centres and paediatric and neurosurgical records. | 253,378 Live born children from 1989-1998 | Sweden | 0.33/1,000 assoc with MMC | 0.33/1,000 assoc with MMC |
Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome. | Mazzini L, Campini R, Angelino E, Rognone F, Pastore I, Oliveri G | 2003 | Adult | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Prospective | Patients referred to an inpatient intensive rehabilitation unit of primary care in a university-based system | 140 patients with severe traumatic brain injury | Turin, Italy | 45% | 440/1,000 severe TBI cases |
Incidence of congenital hydrocephalus and the role of the prenatal diagnosis | Cavalcanti DP, Salomão MA. | 2003 | Neonate | Neonate (Excluding NTD) | Congenital Hydrocephalus | Retrospective | Data were collected from medical records of the Perinatal Genetics Sector (CAISM) | 35,112 live births and still births (>500g) From 1987-1998 | Brazil | 3.16/1,000 births | 3.16/1,000 births |
Congenital hydrocephalus–prevalence and prognosis. Mortality and morbidity in a population-based study | Christensen JH, Hansen LK, Garne E. | 2003 | Neonate | Neonate w/ Birth Defects | Congenital Hydrocephalus | Retrospective | Data for the study were taken from the Eurocat Register of Congenital Malformations for the County of Funen and from medical records | 72,500 births From 1986-1998 | Funen county, Denmark | 0.4/1,000 births | 0.4/1,000 births |
Congenital hydrocephalus 1961-2000–incidence, prenatal diagnosis and prevalence based on maternal age | Sípek A, Gregor V, Horácek J, Masátová D. | 2002 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | Data from the nationwide registration of birth defects were used, kept in in the Institute for Health Information and Statistics of the Czech Republic | 5.75M From 1961-2000 | Czech Republic | 6.35/10,000 live | 0.635/1,000 live |
Post-traumatic hydrocephalus. | Licata C, Cristofori L, Gambin R, Vivenza C, Turazzi S | 2001 | All | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Patients with severe head trauma treated from 1972 to 1999 at the Department of Neurosurgery at the City Hospital of Verona | 4,044 patients with severe head trauma | Verona, Italy | 2.40% | 24/1,000 severe TBI cases | |
Chronic hydrocephalus in elderly patients following subarachnoid hemorrhage. | Yoshioka H, Inagawa T, Tokuda Y, Inokuchi F. | 2000 | Adult | Subarachnoid Hemorrhage | Post Hemorrhagic Hydrocephalus | Prospective | From 1979 to 1996, patients with aneurysmal SAH admitted to the Department of Neurosurgery, Shimane Prefectural Central Hospital and surgically treated | 576 patients | Izumo, Japan | 37% (215/576 Patients) chronic hydrocephalus | 370/1,000 with treated SAH – chronic hydrocephalus |
The incidence of cleft lip, cleft palate, hydrocephalus and spina bifida at Queen Elizabeth Central Hospital, Blantyre, Malawi. | Msamati BC, Igbigbi PS, Chisi JE. | 2000 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | Data from all births at Queen Elizabeth Hospital betwenn 1998 and 1999 | 25,562 births from 1998-1999 | Blantyre, Malawi | 0.47/1,000 hydrocephalus 0.23/1,000 hydrocephalus and spina bifida | 0.47/1,000 births (hydrocephalus) 0.23/1,000 hydrocephalus and spina bifida |
Epidemiology of infantile hydrocephalus in Saudi Arabia: birth prevalence and associated factors. | Murshid WR, Jarallah JS, Dad MI. | 2000 | Neonate | Neonate (Excluding NTD) | Infantile hydrocephalus | Prospective | Conducted over a 1-year period from April 1996 to March 1997 in the city of Al-Madinah Al-Munawarah, Saudi Arabia. Except for neural tube defects and brain tumors, all cases of hydrocephalus diagnosed within the first 28 days of life were included. | 16,250 live births from Apr 1996-Mar 1997 | Saudi Arabia | 1.6/1,000 live births | 1.6/1,000 live births |
Post-traumatic hydrocephalus: experience in 17 consecutive cases. | Phuenpathom N, Ratanalert S, Saeheng S, Sripairojkul B | 1999 | All | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | Patients seen at Songklanagarind Hospital from January 1993 to February 1996 | 1080 head-injured patients 385 severe head injury | Songkhla, Thailand | 1.6% of all TBI 1.8% of severe TBI | 18/1,000 severe TBI cases |
Neural tube defects and congenital hydrocephalus in the Sultanate of Oman. | Rajab A, Vaishnav A, Freeman NV, Patton MA | 1998 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | Data extracted from hospital records betweem 1989 and 1995 | 242,764 births From 1989-1995 | Sultanate of Oman | 0.44/1,000 births | 0.44/1,000 births |
Occurrence of congenital hydrocephalus in the Czech Republic 1961-1995 | Sípek A, Gregor V, Horácek J, Chudobová M, Korandová V, Skibová J. | 1998 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | From a consecutive series of 5,137,907 births in the Czech Republic during 1961-1995 | 5,137,907 births From 1961-1995 | Czech Republic | 3.99/10,000 live born births | 0.399/1,000 live born births |
Posttraumatic ventriculomegaly: hydrocephalus or atrophy? A new approach for diagnosis using CSF dynamics | Marmarou A, Abd-Elfattah Foda MA, Bandoh K, et al | 1996 | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Prospective | Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University | 75 patients with severe head trauma | Richmond, VA | 20% | 200/1,000 severe TBI cases | |
Epidemiology of congenital hydrocephalus in Utah, 1940-1979: report of an iatrogenically related “epidemic” | Blackburn BL, Fineman RM. | 1994 | Neonate | Neonate | Congenital Hydrocephalus | Retrospective | Data were ascertained by examination of multiple sources, e.g., 982,066 birth, 11,161 fetal death, and 248,208 death certificates, and selected hospital and clinic records | 1M neonates from 1940-1979 | Utah | 0.70/1,000 live and still births | 0.70/1,000 live and still births |
Clinico-epidemiologic study of infantile hydrocephalus in Japan | Negoro T, Watanabe K, Nakashima S, Kikuchi H, Tamakoshi A. | 1994 | Neonate | Neonate | Infantile hydrocephalus | A nation-wide survey on congenital hydrocephalus, including secondary hydrocephalus occurring within one year after birth, was carried out in 1988. | Japan’s population | Japan | 0.58/1,000 live births | 0.58/1,000 live births | |
Infantile hydrocephalus in preterm, low-birth-weight infants–a nationwide Swedish cohort study 1979-1988. | Fernell E, Hagberg G, Hagberg B | 1993 | Neonate | Neonate | Infantile hydrocephalus | All Swedish infants with shunt-treated infantile hydrocephalus, born during the period 1979-88 at < or = 34 weeks gestational age and of low birth weight, were studied. | From 1979-1988 | Sweden | 15.9/1,000 live birth, v. preterm 5.1/1,000 live birth, moderate preterm | 15.9/1,000 live birth, v. preterm 5.1/1,000 live birth, moderate preterm | |
Infantile hydrocephalus in the south-western region of Saudi Arabia. | el Awad ME | 1992 | Neonate | Neonate | Infantile hydrocephalus | During the period January 1988 to December 1990 | 74,923 live births | SW Saudi Arabia | 0.81/1,000 live births | 0.81/1,000 live births | |
Pre- and neonatal hydrocephalus in the Middle East: experience in Qatar. | Nogueira GJ | 1992 | Neonate | Neonate | Infantile hydrocephalus | Retrospective | All cases of hydrocephalus diagnosed antenatally or within the first 10 days of life during the period 1986-1989 were reviewed. | 41,402 births From 1986-1989 | Qatar | 157/100,000 live births | 1.57/1,000 live births |
Incidence and neurodevelopmental outcome of periventricular hemorrhage and hydrocephalus in a regional population of very low birth weight infants. | Hanigan WC, Morgan AM, Anderson RJ, Bradle P, Cohen HS, Cusack TJ, Thomas-McCauley T, Miller TC. | 1991 | Neonate | Periventricular Hemorrhage | Post Hemorrhagic Hydrocephalus | Prospective | VLBW infants admitted to a state-designed Level III Neonatal Intensive Care Unit between 1984 and 1987 | 97 VLBW infants w/ PVH (part of a group of 459 VLBW infants) | Illinois, United States | 12% incidence of hydrocephalus associated with high-grade PVH | 120/1,000 with high-grade PVH |
Genetic epidemiologic study of hydrocephalus | Shi MA, Chen YL | 1990 | Neonate | Neonate | Congenital Hydrocephalus | Live and still births were monitered | 77,214 live and still births | China | 1.09% 1.09/1,000 live and still births | 1.09/1,000 live and still births | |
Posttraumatic hydrocephalus–a retrospective review. | Cardoso ER, Galbraith S | 1985 | All | Traumatic Brain Injury | Posttraumatic Hydrocephalus | Retrospective | Patients with hydrocephalus treated in the Institute of Neurological Sciences, Glasgow, between and July 1981 |
2374 cases of severe head injury | Glasgow, Scotland | 0.70% | 7/1,000 severe TBI cases |
Post-traumatic hydrocephalus in patients with severe head injury. | Kishore PR, Lipper MH, Miller JD, Girevendulis AK, Becker DP, Vines FS | 1978 | Traumatic Brain Injury | Posttraumatic Hydrocephalus | 100 consecutive patients with severe TBI | 4% hydro 29% all ventriculomegaly | 40/1,000 severe TBI cases |
Comorbidities
Title
|
Author | Year | Age | Etiology | Comorbidity | Screened | Country | Prevalence |
---|---|---|---|---|---|---|---|---|
Comorbidity of Diabetes Mellitus in Idiopathic Normal Pressure Hydrocephalus: A Systematic Literature Review | Miles Hudson, Caden Nowak, Richard J Garling, Carolyn Harris | 2019 | Adult | Idiopathic Normal Pressure Hydrocephalus | Intellectual Disability | 10 studies | 15.7-17.8% | |
Risk and risk factors for epilepsy in shunt-treated children with hydrocephalus | S Schubert-Bast, L Berghaus, N Filmann, T Freiman, A Strzelczyk, M Kieslich | 2019 | Children | Hydrocephalus | Epilepsy | 361 patients | Germany | 39.60% |
Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus | Vasco Vanhala, Antti Junkkari, Ville E Korhonen, Mitja I Kurki, Mikko Hiltunen, Tuomas Rauramaa, Ossi Nerg, Anne M Koivisto, Anne M Remes, Jonna Perälä, Jaana Suvisaari, Soili M Lehto, Heimo Viinamäki, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen | 2019 | Adult | Idiopathic Normal Pressure Hydrocephalus | Schizophrenia | 521 patients | Finland | 3.10% |
Brain Gliomas, Hydrocephalus and Idiopathic Aqueduct Stenosis in Children With Neurofibromatosis Type 1 | Marie Glombova, Borivoj Petrak, Jiri Lisy, Josef Zamecnik, David Sumerauer, Petr Liby | 2019 | Children | Neurofibromatosis Type 1 | Obstructive Hydrocephalus | 285 patients | Czech Republic | 7.70% |
Prevalence of C9ORF72 Expansion in a Large Series of Patients With Idiopathic Normal-Pressure Hydrocephalus | Ville E Korhonen, Anne M Remes, Seppo Helisalmi, Tuomas Rauramaa, Anna Sutela, Ritva Vanninen, Noora-Maria Suhonen, Annakaisa Haapasalo, Mikko Hiltunen, Juha E Jääskeläinen, Hilkka Soininen, Anne M Koivisto, Ville Leinonen | 2019 | Adult | possible Idiopathic Normal Pressure Hydrocephalus | C9ORF72 Expanision | 487 patients | Finland | 1.60% |
Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus | Okko T Pyykkö, Ossi Nerg, Hanna-Mari Niskasaari, Timo Niskasaari, Anne M Koivisto, Mikko Hiltunen, Jussi Pihlajamäki, Tuomas Rauramaa, Maria Kojoukhova, Irina Alafuzoff, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Hypertension | 283 patients | Finland | 52% |
Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus | Okko T Pyykkö, Ossi Nerg, Hanna-Mari Niskasaari, Timo Niskasaari, Anne M Koivisto, Mikko Hiltunen, Jussi Pihlajamäki, Tuomas Rauramaa, Maria Kojoukhova, Irina Alafuzoff, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Type 2 Diabetes Mellitus | 283 patients | Finland | 23% |
Brain comorbidities in normal pressure hydrocephalus | G. Allali, M. Laidet, S. Armand, and F. Assal | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Alzheimer’s | 52 patients | Switzerland | 56% |
Brain comorbidities in normal pressure hydrocephalus | G. Allali, M. Laidet, S. Armand, and F. Assal | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Cerebrovascular White Matter Disease | 52 patients | Switzerland | 40% |
Brain comorbidities in normal pressure hydrocephalus | G. Allali, M. Laidet, S. Armand, and F. Assal | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Parkinsonism | 52 patients | Switzerland | 17% |
Long-term effects of complications and vascular comorbidity in idiopathic normal pressure hydrocephalus: a quality registry study | Kerstin Andrén, Carsten Wikkelsö, Nina Sundström, Simon Agerskov, Hanna Israelsson, Katarina Laurell, Per Hellström, and Mats Tullberg | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Diabetes Mellitus | 979 patients | Sweden | 21% |
Long-term effects of complications and vascular comorbidity in idiopathic normal pressure hydrocephalus: a quality registry study | Kerstin Andrén, Carsten Wikkelsö, Nina Sundström, Simon Agerskov, Hanna Israelsson, Katarina Laurell, Per Hellström, and Mats Tullberg | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Hypertension | 979 patients | Sweden | 49% |
Long-term effects of complications and vascular comorbidity in idiopathic normal pressure hydrocephalus: a quality registry study | Kerstin Andrén, Carsten Wikkelsö, Nina Sundström, Simon Agerskov, Hanna Israelsson, Katarina Laurell, Per Hellström, and Mats Tullberg | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Heart Disease | 979 patients | Sweden | 26% |
Epilepsy, headache, and abdominal pain after shunt surgery for idiopathic normal pressure hydrocephalus: the INPH-CRasH study | Jenny Larsson, Hanna Israelsson, Anders Eklund, Jan Malm | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Epilepsy | 176 patients | Sweden | 4.50% |
Symptomatic Communicating Hydrocephalus in a Contemporary Cohort of High Grade Glioma Patients | Thomas Beez, Sven Burgula, Marcel Kamp, Marion Rapp, Hans-Jakob Steiger, Michael Sabel | 2018 | Adult | High Grade Glioma | Communicating Hydrocephalus | 278 patients | Germany | 3% |
Idiopathic Normal-Pressure Hydrocephalus and Obstructive Sleep Apnea Are Frequently Associated: A Prospective Cohort Study | Gustavo C Román, Aparajitha K Verma, Y Jonathan Zhang, Steve H Fung | 2018 | Adult | Idiopathic Normal Pressure Hydrocephalus | Obstructive Sleep Apnea | 31 patients | USA | 90.30% |
Nationwide hospital‐based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics | Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Ura, Hajime Arai | 2017 | Adult | Idiopathic Normal Pressure Hydrocephalus | Hypertension | 1524 patients | Japan | 40% |
Nationwide hospital‐based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics | Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Ura, Hajime Arai | 2017 | Adult | Idiopathic Normal Pressure Hydrocephalus | Diabetes Mellitus | 1524 patients | Japan | 17.80% |
Nationwide hospital‐based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics | Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Ura, Hajime Arai | 2017 | Adult | Idiopathic Normal Pressure Hydrocephalus | Alzheimer’s | 1524 patients | Japan | 14.80% |
Papilledema in Children With Hydrocephalus: Incidence and Associated Factors | Haeng Jin Lee, Ji Hoon Phi, Seung-Ki Kim, Kyu-Chang Wang, Seong-Joon Kim | 2017 | Children | Hydrocephalus | Papilledema | 46 patients | Korea | 59% |
Parkinsonism Differentiates Idiopathic Normal Pressure Hydrocephalus From Its Mimics | Gilles Allali, Valentina Garibottoc, and Frederic Assal | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Parkinsonism | 79 patients | Switzerland | 20.30% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Non-Communicating Hydrocephalus | Arterial Hypertension | 50 patients | Norway | 32% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Arterial Hypertension | 176 patients | Norway | 40.90% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Non-Communicating Hydrocephalus | Angina Pectoris | 50 patients | Norway | 4% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Angina Pectoris | 176 patients | Norway | 9.10% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Non-Communicating Hydrocephalus | Cardiac Infarction | 50 patients | Norway | 8% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Cardiac Infarction | 176 patients | Norway | 8.50% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Non-Communicating Hydrocephalus | Diabetes Mellitus | 50 patients | Norway | 12% |
The Prevalence of Cardiovascular Disease in Non-Communicating Hydrocephalus | Per Kristian Eide, Are Hugo Pripp | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Diabetes Mellitus | 176 patients | Norway | 14.80% |
Cerebral Microbleeds in Idiopathic Normal Pressure Hydrocephalus | Elias Johansson, Khalid Ambarki, Richard Birgander, Nazila Bahrami, Anders Eklund, Jan Malm | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Cerebral Microbleeds | 14 patients | Sweden | 43% |
Cerebral Microbleeds in Idiopathic Normal Pressure Hydrocephalus | Elias Johansson, Khalid Ambarki, Richard Birgander, Nazila Bahrami, Anders Eklund, Jan Malm | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Cerebral Microbleeds | 14 patients | Sweden | 29% |
Symptoms of Depression Are Common in Patients With Idiopathic Normal Pressure Hydrocephalus: The INPH-CRasH Study | Hanna Israelsson, Per Allard, Anders Eklund, Jan Malm | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Cerebrovascular Disease | 176 patients | Sweden | 25% |
Symptoms of Depression Are Common in Patients With Idiopathic Normal Pressure Hydrocephalus: The INPH-CRasH Study | Hanna Israelsson, Per Allard, Anders Eklund, Jan Malm | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Hypertension | 176 patients | Sweden | 83% |
Symptoms of Depression Are Common in Patients With Idiopathic Normal Pressure Hydrocephalus: The INPH-CRasH Study | Hanna Israelsson, Per Allard, Anders Eklund, Jan Malm | 2016 | Adult | Idiopathic Normal Pressure Hydrocephalus | Depression | 176 patients | Sweden | 46% |
Chiari malformation Type I surgery in pediatric patients. Part 2: complications and the influence of comorbid disease in California, Florida, and New York | Jacob K Greenberg, Margaret A Olsen, Chester K Yarbrough, Travis R Ladner, Chevis N Shannon, Jay F Piccirillo, Richard C E Anderson, John C Wellons 3rd, Matthew D Smyth, Tae Sung Park, David D Limbrick Jr | 2016 | Children | Chiari Malformation Type 1 | Hydrocephalus | 936 patients | USA | 6.50% |
Patients Exposed to Diagnostic Head and Neck Radiation for the Management of Shunted Hydrocephalus Have a Significant Risk of Developing Thyroid Nodules | Jennifer H Aldrink, Brent Adler, Jesse Haines, Daniel Watkins, Mika Matthews, Lacey Lubeley, Wei Wang, Denis R King | 2016 | All | Shunted Hydrocephalus | Thyroid Nodules | 112 patients | USA | 13.60% |
Analysis of risk factors to predict communicating hydrocephalus following gamma knife radiosurgery for intracranial schwannoma | Seunghoon Lee, Seong-Wook Seo, Juyoung Hwang, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Doo-Sik Kong | 2016 | All | Intracranial Schwannoma treated w/ gamma knife radiosurgery | Communicating Hydrocephalus | 702 patients | Korea | 4.10% |
Increased Risk of Hydrocephalus in Long-Term Dialysis Patients | I-Kuan Wang, Cheng-Li Lin, Yu-Kai Cheng, Che-Yi Chou, Chih-Chia Liang, Tzung-Hai Yen, Fung-Chang Sung | 2016 | Adult | End Stage Renal Failure | Hydrocephalus | 29,684 patients | Taiwan | 0.38% |
Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus. | Elobeid A, Laurell K, Cesarini KG, Alafuzoff I. | 2015 | Adult | Idiopathic Normal Pressure Hydrocephalus | Alzheimer’s | 111 biopsy samples | 47% | |
A Predictive Model of Unfavorable Outcomes After Benign Intracranial Tumor Resection | Kimon Bekelis, Piyush Kalakoti, Anil Nanda, Symeon Missios | 2015 | Adult | Benign Intracranial Tumor Resection | Hydrocephalus | 19,894 patients | USA | 4.20% |
Psychiatric symptoms are present in most of the patients with idiopathic normal pressure hydrocephalus. | Oliveira MF, Oliveira JR, Rotta JM, Pinto FC. | 2014 | Adult | Idiopathic Normal Pressure Hydrocephalus | Psychiatric Syndromes | 35 patients | 71.42% | |
Visual function in infants with congenital hydrocephalus with and without myelomeningocoele | Idowu OE, Balogun MM. | 2013 | Children | Congenital hydrocephalus associated with myelomeningocele | Optic Atrophy | 50 patients | 18% | |
Post-hemispherectomy hydrocephalus: results of a comprehensive, multi-institutional review | Lew SM, Matthews AE, Hartman AL, Haranhalli N; Post-Hemispherectomy Hydrocephalus Workgroup. | 2012 | Children | Acquired Hydrocephalus | Epilepsy | 736 patients (who underwent hemispherectomy for epilepsy) | USA and Japan | 23% (required treatment for hydrocpehalus) |
Idiopathic normal‐pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting | R Bech‐Azeddine, P Høgh, M Juhler, F Gjerris, and G Waldemar | 2007 | Adult | Idiopathic Normal Pressure Hydrocephalus | Alzheimer’s | 28 patients | 42.90% | |
Idiopathic normal‐pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting | R Bech‐Azeddine, P Høgh, M Juhler, F Gjerris, and G Waldemar | 2007 | Adult | Idiopathic Normal Pressure Hydrocephalus | Cerebrovascular Disease | 28 patients | 60.70% | |
Hydrocephalus in children born in 1999-2002: epidemiology, outcome and ophthalmological findings. | Persson EK, Anderson S, Wiklund LM, Uvebrant P. | 2007 | Children | Infantile or associated with myelomeningocele | Ophthalmological Abnormalities | 40 patients | Sweden | 80% |
Behavioural problems and autism in children with hydrocephalus : a population-based study. | Lindquist B, Carlsson G, Persson EK, Uvebrant P. | 2006 | Children | Infantile Hydrocephalus | Autism | 41 patients | Sweden | 20% |
Behavioural problems and autism in children with hydrocephalus : a population-based study. | Lindquist B, Carlsson G, Persson EK, Uvebrant P. | 2006 | Children | Associated with myelomeningocele | Autism | 26 patients | Sweden | 3.85% |
Behavioural problems and autism in children with hydrocephalus : a population-based study. | Lindquist B, Carlsson G, Persson EK, Uvebrant P. | 2006 | Children | Infantile or associated with myelomeningocele | Behavioural Problems | 67 pateints | Sweden | 39% |
Disabilities in children with hydrocephalus–a population-based study of children aged between four and twelve years. | Persson EK, Hagberg G, Uvebrant P. | 2006 | Children | Infantile Hydrocephalus | Cerebral Palsy | 70 patients | Sweden | 27% |
Disabilities in children with hydrocephalus–a population-based study of children aged between four and twelve years. | Persson EK, Hagberg G, Uvebrant P. | 2006 | Children | Infantile Hydrocephalus | Epilepsy | 70 patients | Sweden | 34% |
Disabilities in children with hydrocephalus–a population-based study of children aged between four and twelve years. | Persson EK, Hagberg G, Uvebrant P. | 2006 | Children | Associated with myelomeningocele | Epilepsy | 44 patients | Sweden | 11% |
Disabilities in children with hydrocephalus–a population-based study of children aged between four and twelve years. | Persson EK, Hagberg G, Uvebrant P. | 2006 | Children | Infantile Hydrocephalus | Learning disabilities | 70 patients | Sweden | 47% |
Disabilities in children with hydrocephalus–a population-based study of children aged between four and twelve years. | Persson EK, Hagberg G, Uvebrant P. | 2006 | Children | Associated with myelomeningocele | Learning disabilities | 44 patients | Sweden | 16% |
Are some cases of spina bifida combined with cerebral palsy? A study of 28 cases. | Ozaras N, Yalcin S, Ofluoglu D, Gureri B, Cabukoglu C, Erol B. | 2005 | Children | Associated with meningomyelocele | Cerebral Palsy | 365 patients | 7.70% | |
Epilepsy in shunted posthemorrhagic infantile hydrocephalus owing to pre- or perinatal intra- or periventricular hemorrhage. | Battaglia D, Pasca MG, Cesarini L, Tartaglione T, Acquafondata C, Randò T, Veredice C, Ricci D, Guzzetta F. | 2005 | Children | Shunted Post Hemmorhagic Hydrocephalus | Epilepsy | 40 patients | 67.50% | |
Prevalence of hydrocephalus in 157 patients with vestibular schwannoma. | Rogg JM, Ahn SH, Tung GA, Reinert SE, Norén G. | 2005 | Adult | Vestibular Schwannoma | Hydrocephalus | 157 pateints | USA | 18% |
Epilepsy in shunt-treated hydrocephalus. | Klepper J, Büsse M, Strassburg HM, Sörensen N. | 1998 | All | Shunted Hydrocephalus | Epilepsy | 182 pateints | Germany | 20% |
Epilepsy in Children with Meningomyelocele | Talwar et al. | 1995 | Children | Associated with meningomyelocele | Epilepsy | 81 patients | USA | 17.30% |
Epilepsy in Children with Meningomyelocele | Talwar et al. | 1995 | Children | Associated with meningomyelocele | Seizures | 81 patients | USA | 21.00% |
Autistic symptoms in children with infantile hydrocephalus. | Fernell E, Gillberg C, von Wendt L. | 1991 | Children | Infantile Hydrocephalus | Autism | 69 patients | Sweden | 23% |
Autistic symptoms in children with infantile hydrocephalus. | Fernell E, Gillberg C, von Wendt L. | 1991 | Children | Infantile Hydrocephalus | Cerebral Palsy | 53 patients | Sweden | 19% |
Autistic symptoms in children with infantile hydrocephalus. | Fernell E, Gillberg C, von Wendt L. | 1991 | Children | Infantile Hydrocephalus | Epilepsy | 53 patients | Sweden | 9% |
Autistic symptoms in children with infantile hydrocephalus. | Fernell E, Gillberg C, von Wendt L. | 1991 | Children | Infantile Hydrocephalus | Mental Retardation | 53 patients | Sweden | 23% |
Epidemiology of Infantile Hydrocephalus in Sweden: A Clinical Follow-Up Study in Children Born at Term | Fernell et al | 1988 | Children | Infantile Hydrocephalus | Cerebral Palsy | 68 patients | Sweden | 28% |
Epidemiology of Infantile Hydrocephalus in Sweden: A Clinical Follow-Up Study in Children Born at Term | Fernell et al | 1988 | Children | Infantile Hydrocephalus | Epilepsy | 68 patients | Sweden | 22% |
Epidemiology of Infantile Hydrocephalus in Sweden: A Clinical Follow-Up Study in Children Born at Term | Fernell et al | 1988 | Children | Infantile Hydrocephalus | Intellectual Disability | 68 patients | Sweden | 38% |
Epidemiology of Infantile Hydrocephalus in Sweden: A Clinical Follow-Up Study in Children Born at Term | Fernell et al | 1988 | Children | Infantile Hydrocephalus | Minor Motor Dysfunction | 68 patients | Sweden | 25% |
The incidence of epilepsy after ventricular shunting procedures | Dan et al. | 1986 | All | Shunted Hydrocephalus | Seizures | 207 patients | USA | 9.40% |
Genetics
Title
|
Authors | Year | Species | Strain | Clinical Form | Trait | Locus | Chromosome | Human Syntenic Region | Human Gene |
---|---|---|---|---|---|---|---|---|---|---|
Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus | Shizuka Konishi, Natsuki Tanaka, Tomoji Mashimo, Takashi Yamamoto, Tetsushi Sakuma, Takehito Kaneko, Miyuu Tanaka, Takeshi Izawa, Jyoji Yamate, Mitsuru Kuwamura | 2020 | Rat | F344-Ccdc85cem1Kyo | Congenital | Autosomal Recessive | Ccdc85c | 6 | 14 | CCDC85C |
De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry | Julia Wallmeier, Diana Frank, Amelia Shoemark, Tabea Nöthe-Menchen, Sandra Cindric et al. | 2019 | Human | n/a | hydrocephalus associated with PCD | Autosomal Dominant | FOXJ1 | 17q25.1 | n/a | FOXJ1 |
SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus | Sheng Chih Jin, Charuta G Furey, Xue Zeng, August Allocco, Carol Nelson-Williams, Weilai Dong, Jason K Karimy, Kevin Wang, Shaojie Ma, Eric Delpire 4, Kristopher T Kahle | 2019 | Human | n/a | Congenital | unknown | SLC12A6 | 15 | n/a | SLC12A6 |
SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus | Sheng Chih Jin, Charuta G Furey, Xue Zeng, August Allocco, Carol Nelson-Williams, Weilai Dong, Jason K Karimy, Kevin Wang, Shaojie Ma, Eric Delpire 4, Kristopher T Kahle | 2019 | Human | n/a | Congenital | unknown | SLC12A7 | 5 | n/a | SLC12A7 |
Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities | Yoshiro Morimoto, Shintaro Yoshida, Akira Kinoshita, Chisei Satoh, Hiroyuki Mishima et al. | 2019 | Human | n/a | NPH | Autosomal Dominant | CFAP43 | 10 | n/a | CFAP43 |
A recurrent de novo missense pathogenic variant in SMARCB1 causes severe intellectual disability and choroid plexus hyperplasia with resultant hydrocephalus | Illja J Diets, Trine Prescott, Neena L Champaigne, Grazia M S Mancini, Bård Krossnes, Radek Frič, Kristina Kocsis, Marjolijn C J Jongmans, Tjitske Kleefstra | 2019 | Human | n/a | Congenital | Autosomal Dominant | SMARCB1 | 22q11.23 | n/a | SMARCB1 |
Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities | Issei S Shimada, Bandarigoda N Somatilaka, Sun-Hee Hwang, Ashley G Anderson, John M Shelton, Veena Rajaram, Genevieve Konopka, Saikat Mukhopadhyay | 2019 | Mouse | C57BL/6J background | Congenital | unknown | Gpr161 | 1 | 1 | GPR161 |
A novel ISLR2-linked autosomal recessive syndrome of congenital hydrocephalus, arthrogryposis and abdominal distension | Anas M Alazami, Sateesh Maddirevula, Mohamed Zain Seidahmed, Lulu A Albhlal, Fowzan S Alkuraya | 2019 | Human | n/a | Congenital | Autosomal Recessive | ISLR2 | 15 | n/a | ISLR2 |
Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation | Joon W Shim, Paul R Territo, Stefanie Simpson, John C Watson, Lei Jiang, Amanda A Riley, Brian McCarthy, Scott Persohn, Daniel Fulkerson, Bonnie L Blazer-Yost | 2019 | Rat | wpk | hydrocephalus associated with Meckel-Gruber syndrome | TMEM67 | 8q11.23-q24.22 | 8q22.12-q22.1 | TMEM67 | |
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation | Dustin L Gable, Valeriya Gaysinskaya, Christine C Atik, C Conover Talbot Jr, Byunghak Kang, Susan E Stanley, Elizabeth W Pugh, Nuria Amat-Codina, Kara M Schenk, Murat O Arcasoy, Cory Brayton5, Liliana Florea, Mary Armanios | 2019 | Mice | C57BL/6J background | Congenital | Zcchc8 | 5 | 12 | ZCCHC8 | |
A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice | Zakia Abdelhamed, Shawn M. Vuong, Lauren Hill, Crystal Shula, Andrew Timms, David Beier, Kenneth Campbell, Francesco T. Mangano, Rolf W. Stottmann, and June Goto | 2018 | Mouse | Ccdc39tm1a [Ccdc39tm1a(KOMP)Wtsi] | Congenital | Autosomal Recessive | Ccdc39 | 3 | ||
De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus | Charuta Gavankar Furey, Jungmin Choi, Sheng Chih Jin, Xue Zeng, Andrew T Timberlake et al. | 2018 | Human | n/a | Congenital | unknown | TRIM71 | 3 | TRIM71 | |
De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus | Charuta Gavankar Furey, Jungmin Choi, Sheng Chih Jin, Xue Zeng, Andrew T Timberlake et al. | 2018 | Human | n/a | Congenital | unknown | SMARCC1 | 3 | SMARCC1 | |
De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus | Charuta Gavankar Furey, Jungmin Choi, Sheng Chih Jin, Xue Zeng, Andrew T Timberlake et al. | 2018 | Human | n/a | Congenital | unknown | PTCH1 | 9 | PTCH1 | |
De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus | Charuta Gavankar Furey, Jungmin Choi, Sheng Chih Jin, Xue Zeng, Andrew T Timberlake et al. | 2018 | Human | n/a | Congenital | unknown | SHH | 7 | SHH | |
Strain-specific differences in brain gene expression in a hydrocephalic mouse model with motile cilia dysfunction | Casey W. McKenzie, Claudia C. Preston, Rozzy Finn, Kathleen M. Eyster, Randolph S. Faustino, and Lance Lee | 2018 | Mouse | nm1054 | hydrocephalus associated with PCD | Autosomal Recessive | Cfap221 | 1 | 2 | CFAP21 |
Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus | Claudia Dafinger, Markus M Rinschen, Lori Borgal, Carolin Ehrenberg, Sander G Basten et al. | 2018 | Mouse | C57BL/6N background | Congenital | unknown | Ruvbl1 | 6 | 3 | RUVBL1 |
Gain-of-function mutations in the protein tyrosine phosphatase Ptpn11 (SHP2) induce hydrocephalus in a catalytically-dependent manner | Hong Zheng, Wen-Mei Yu, Ronald R. Waclaw, Maria I. Kontaridis, Benjamin G. Neel, and Cheng-Kui Qu1 | 2018 | Mouse | Ptpn11E76K,C459S/+ | Congenital | Autosomal Dominant | Ptpn11 | 5 | 12 | PTPN11 |
Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice | Anja Feldner, M Gordian Adam, Fabian Tetzlaff, Iris Moll, Dorde Komljenovic, Felix Sahm, Tobias Bäuerle, Hiroshi Ishikawa, Horst Schroten, Thomas Korff, Ilse Hofmann, Hartwig Wolburg, Andreas von Deimling, and Andreas Fischer | 2017 | Mouse | Mpdz Gt(XG734)Byg(+/−)1AFis*C57BL/6 | Congenital | Autosomal Recessive | Mpdz | 9p23 | ||
The Genetic Landscape of Familial Congenital Hydrocephalus | Ranad Shaheen, Mohammed Adeeb Sebai, Nisha Patel, Nour Ewida, Wesam Kurdi, Ikhlass Altweijri, Sameera Sogaty, Elham Almardawi, Mohammed Zain Seidahmed, Abdulrahman Alnemri, Sateesh Madirevula, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Tarfa Al-Sheddi, Rana Alomar, Eman Alobeid, Bahauddin Sallout, Badi AlBaqawi, Wajeih AlAali, Nouf Ajaji, Harry Lesmana, Robert J Hopkin, Lucie Dupuis, Roberto Mendoza-Londono, Hadeel Al Rukban, Grace Yoon, Eissa Faqeih, Fowzan S Alkuraya | 2017 | Human | n/a | Congenital | Autosomal Recessive | WDR81 | 17 | WDR81 | |
The Genetic Landscape of Familial Congenital Hydrocephalus | Ranad Shaheen, Mohammed Adeeb Sebai, Nisha Patel, Nour Ewida, Wesam Kurdi, Ikhlass Altweijri, Sameera Sogaty, Elham Almardawi, Mohammed Zain Seidahmed, Abdulrahman Alnemri, Sateesh Madirevula, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Tarfa Al-Sheddi, Rana Alomar, Eman Alobeid, Bahauddin Sallout, Badi AlBaqawi, Wajeih AlAali, Nouf Ajaji, Harry Lesmana, Robert J Hopkin, Lucie Dupuis, Roberto Mendoza-Londono, Hadeel Al Rukban, Grace Yoon, Eissa Faqeih, Fowzan S Alkuraya | 2017 | Human | n/a | Congenital | unknown | EML1 | 14 | EML1 | |
The Genetic Landscape of Familial Congenital Hydrocephalus | Ranad Shaheen, Mohammed Adeeb Sebai, Nisha Patel, Nour Ewida, Wesam Kurdi, Ikhlass Altweijri, Sameera Sogaty, Elham Almardawi, Mohammed Zain Seidahmed, Abdulrahman Alnemri, Sateesh Madirevula, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Tarfa Al-Sheddi, Rana Alomar, Eman Alobeid, Bahauddin Sallout, Badi AlBaqawi, Wajeih AlAali, Nouf Ajaji, Harry Lesmana, Robert J Hopkin, Lucie Dupuis, Roberto Mendoza-Londono, Hadeel Al Rukban, Grace Yoon, Eissa Faqeih, Fowzan S Alkuraya | 2017 | Human | n/a | Congenital | Autosomal Recessive | MPDZ | 9 | MPDZ | |
Ulk4 Is Essential for Ciliogenesis and CSF Flow | Min Liu, Zhenlong Guan,Qin Shen, Pierce Lalor, Una Fitzgerald, Timothy O’Brien, Peter Dockery, and Sanbing Shen | 2016 | Mouse | Ulk4tm1a(KOMP)Wtsi | Congenital | unknown | Ulk4 | 9 | 3 | ULK4 |
SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis | Xin Wang, Ying Zhou, Jian Wang, I-Chu Tseng, Timothy Huang et al. | 2016 | Mouse | C57BL/6 and 129SV mixed backgrounds | Congenital | Autosomal Dominant | Snx27 | 3 | 1 | SNX27 |
Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice | Seungshin Ha, Anna M Lindsay, Andrew E Timms, David R Beier | 2016 | Mouse | C57BL6/N background | hydrocephalus associated with PCD | Autosomal Recessive | Dnaaf1 | 8 | 16 | DNAAF1 |
Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice | Seungshin Ha, Anna M Lindsay, Andrew E Timms, David R Beier | 2016 | Mouse | C57BL6/N background | hydrocephalus associated with PCD | Autosomal Recessive | Lrrc48 | 11 | 17 | LRRC48 |
Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus | Joon W Shim, Johanna Sandlund, Mustafa Q Hameed, Bonnie Blazer-Yost, Feng C Zhou, Michael Klagsbrun, Joseph R Madsen | 2016 | Mice | C57BL6 | SAH/PHH | HB-EGF | human HB-EGF introduced | 5 | HB-EGF | |
CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice | Casey W McKenzie, Branch Craige, Tiffany V Kroeger, Rozzy Finn, Todd A Wyatt, Joseph H Sisson, Jacqueline A Pavlik, Lara Strittmatter, Gregory M Hendricks, George B Witman, Lance Lee | 2015 | Mouse | C57BL6/J (B6) background | hydrocephalus associated with PCD | Autosomal Recessive | Cfap54 | 10 | 12 | CFAP54 |
Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy | Achira Roy, Jonathan Skibo, Franck Kalume, Jing Ni, Sherri Rankin, Yiling Lu, William B Dobyns, Gordon B Mills, Jean J Zhao, Suzanne J Baker, and Kathleen J Millen | 2015 | Mouse | Pik3caH1047R and Pik3caE545K | Congenital | unknown | Pik3ca | 3 | 3 | PIK3ca |
A nonsense mutation in B3GALNT2 is concordant with hydrocephalus in Friesian horses | Bart J. Ducro, Anouk Schurink, John W. M. Bastiaansen, Iris J. M. Boegheim, Frank G. van Steenbeek, Manon Vos-Loohuis, Isaac J. Nijman, Glen R. Monroe, Ids Hellinga, Bert W. Dibbits, Willem Back, and Peter A. J. Leegwater | 2015 | Horse | Friesian | Congenital | Autosomal Recessive | B3GALNT2 | 1 | 1 | B3GALNT2 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Ulk4 | 9 | 3 | ULK4 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Nme5 | 18 | 5 | NME5 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Nme7 | 1 | 1 | NME7 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Kif27 | 13 | 9 | KIF7 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Stk36 | 1 | 2 | STK36 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Dpcd/Poll | 19 | 10 | DPCD/POLL |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Ak7 | 12 | 14 | AK7 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Ak8 | 2 | 9 | AK8 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | 4930444A02Rik | 8 | ||
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Celsr2 | 3 | 1 | CELRS2 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Mboat7 | 7 | 19 | MBOAT7 |
Congenital hydrocephalus in genetically engineered mice | P Vogel, R W Read, G M Hansen, B J Payne, D Small, A T Sands, B P Zambrowicz | 2012 | Mouse | C57BL/6 and 129 background | Congenital | Autosomal Recessive | Fzd3 | 14 | 8 | FZD3 |
Loss of SPEF2 Function in Mice Results in Spermatogenesis Defects and Primary Ciliary Dyskinesia | Anu Sironen, Noora Kotaja, Howard Mulhern, Todd A. Wyatt, Joseph H. Sisson, Jacqueline A. Pavlik, Mari Miiluniemi, Mark D. Fleming, and Lance Lee | 2011 | Mouse | C57BL/6J;C57BL/10J background | hydrocephalus associated with PCD | Autosomal Recessive | Spef2 | 15 | 5 | SPEF2 |
Lysophosphatidic acid signaling may initiate fetal hydrocephalus | Yun C Yung, Tetsuji Mutoh, Mu-En Lin, Kyoko Noguchi, Richard R Rivera, Ji Woong Choi, Marcy A Kingsbury, Jerold Chun | 2011 | Mice | Congenital | LPAR1 | 9 | LPAR1 | |||
Disturbed Wnt Signalling Due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus With Medial Diverticulum | A B Ekici, D Hilfinger, M Jatzwauk, C T Thiel, D Wenzel, I Lorenz, E Boltshauser, T W Goecke, G Staatz, D J Morris-Rosendahl, H Sticht, U Hehr, A Reis, A Rauch | 2010 | Human | n/a | Congenital | Autosomal Recessive | CCDC88C | 14 | CCDC88C | |
Mutation of Murine Adenylate Kinase 7 Underlies a Primary Ciliary Dyskinesia Phenotype | Angeles Fernandez-Gonzalez, Stella Kourembanas, Todd A. Wyatt, and S. Alex Mitsialis | 2009 | Mouse | C57BL/6 background | hydrocephalus associated with PCD | unknown | Ak7 | 12 | 14 | AK7 |
The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat | Ursula M Smith, Mark Consugar, Louise J Tee, Brandy M McKee, Esther N Maina et al. | 2006 | Rat | wpk | hydrocephalus associated with Meckel-Gruber syndrome | TMEM67 | 8q11.23-q24.22 | 8q22.12-q22.1 | TMEM67 | |
Genetic analysis of inherited hydrocephalus in a rat model. | Jones HC, Yehia B, Chen GF, et al. | 2004 | Rat | HTX | Congenital | Quantitative Trait Locus | D9Rat2 | 9q38 | 5q21.1, 18p11.22-31 | |
Genetic analysis of inherited hydrocephalus in a rat model. | Jones HC, Yehia B, Chen GF, et al. | 2004 | Rat | HTX | Congenital | Quantitative Trait Locus | D10Rat136, D10Rat135 | 10q32.1-10q32.3 | 17q21.3-q25.3 | |
Genetic analysis of inherited hydrocephalus in a rat model. | Jones HC, Yehia B, Chen GF, et al. | 2004 | Rat | HTX | Congenital | Quantitative Trait Locus | D11Arb2, D11Rat46 | 11q23 | 3q27-28, 22q11.21, 10p12.2 | |
Genetic analysis of inherited hydrocephalus in a rat model. | Jones HC, Yehia B, Chen GF, et al. | 2004 | Rat | HTX | Congenital | Quantitative Trait Locus | D17Mit4, D17Rat154 | 17q12.1 | 1q43, 10p11.21-p13 | |
The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice | Hong HK, Chakravarti A, Takahashi JS | 2004 | Mouse | C57BL/10J | Congenital | Autosomal Recessive | hyh | 7 | 19q13.3 | a-SNAP |
The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. | Chae TH, Kim S, Marz KE, et al. | 2004 | Mouse | C57BL/10J | Congenital | Autosomal Recessive | hyh | 7 | 19q13.3 | a-SNAP |
Hemorrhagic hydrocephalus (hhy): a novel mutation on mouse chromosome 12. | Kuwamura M, Kinoshita A, Okumoto M, et al. | 2004 | Mouse | BALB/cHeA | Congenital | Autosomal Recessive | hhy | 12 | 14q32 | |
Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. | Ibanez-Tallon I, Pagenstecher A, Fliegauf M, et al. | 2004 | Mouse | C57BL/6*CBA/j | Congenital | Autosomal Recessive | Mdnah5 | 15 | 5p15.2 | DNAHS |
Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus. | Fernandez-Llebrez P, Grondona JM, Perez J, et al. | 2004 | Mouse | 129P2/OlaHsd | Congenital | Autosomal Recessive | Msx1 | 5 | 4p16.3-p16.1 | MSX1 |
Msx1 disruption leads to diencephalon defects and hydrocephalus. | Ramos C, Fernandez-Llebrez P, Bach A, et al. | 2004 | Mouse | 129P2/OlaHsd | Congenital | Autosomal Recessive | Msx1 | 5 | 4p16.3-p16.1 | MSX1 |
Development of hydrocephalus in mice lacking SOCS7. | Krebs DL, Metcalf D, Merson TD, et al. | 2004 | Mouse | C5BL/6 | Congenital | Autosomal Recessive | Socs7 | 11 | 17q12 | SOCS7 |
Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease. | Jones HC, Carter BJ, Morel L | 2003 | Rat | LEW/Jms | Congenital | Autosomal Recessive, Quantitative Trait Locus | uknown | unknown | ||
Quantitative trait loci modulate ventricular size in the mouse brain. | Zygourakis CC, Rosen GD | 2003 | Mouse | C57BL/6J | Congenital | Quantitative Trait Locus | Vent8a | 8 | 8p11-23, 13q11-34 | |
Quantitative trait loci modulate ventricular size in the mouse brain. | Zygourakis CC, Rosen GD | 2003 | Mouse | C57BL/6J | Congenital | Quantitative Trait Locus | Vent4b | 4 | 6p, 9 | |
Quantitative trait loci modulate ventricular size in the mouse brain. | Zygourakis CC, Rosen GD | 2003 | Mouse | C57BL/6J | Congenital | Quantitative Trait Locus | Vent7c | 7 | 19q10-13 | |
Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. | Davy BE, Robinson ML | 2003 | Mouse | hy3 | Congenital | Autosomal Recessive | Hydin | 8 | 16q22.2 | HYDIN |
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. | Blackshear PJ, Graves JP, Stumpo DJ, et al. | 2003 | Mouse | C57BL6/J | Congenital | Autosomal Dominant | Rfx4 | 10 | 12q24 | RFX4 |
The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats. | Jones HC, Depelteau JS, Carter BJ, et al. | 2002 | Rat | HTX | Congenital | Quantitative Trait Locus | D9Rat2 | 9q38 | 5q21.1, 18p11.22-31 | |
The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats. | Jones HC, Depelteau JS, Carter BJ, et al. | 2002 | Rat | HTX | Congenital | Quantitative Trait Locus | D10Rat136, D10Rat135 | 10q32.1-10q32.3 | 17q21.3-q25.3 | |
The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats. | Jones HC, Depelteau JS, Carter BJ, et al. | 2002 | Rat | HTX | Congenital | Quantitative Trait Locus | D11Arb2, D11Rat46 | 11q23 | 3q27-28, 22q11.21, 10p12.2 | |
The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats. | Jones HC, Depelteau JS, Carter BJ, et al. | 2002 | Rat | HTX | Congenital | Quantitative Trait Locus | D17Mit4, D17Rat154 | 17q12.1 | 1q43, 10p11.21-p13 | |
Genetic mapping of an insertional hydrocephalus-inducing mutation allelic to hy3 | Robinson ML, Allen CE, Davy BE, et al. | 2002 | Mouse | hy3 | Congenital | Autosomal Recessive | Hydin | 8 | 16q22.2 | HYDIN |
Congenital hydranencephalic-hydrocephalic syndrome with proliferative vasculopathy: a possible relation with mitochondrial dysfunction. | Castro-Gago M, Pintos-Martinez E, Forteza-Vila J, et al. | 2001 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat. | Jones HC, Carter BJ, Depelteau JS, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D9Rat2 | 9q38 | 5q21.1, 18p11.22-31 | |
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Mamm Genome | Jones HC, Depelteau JS, Carter BJ, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D9Rat2 | 9q38 | 5q21.1, 18p11.22-31 | |
Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat. | Jones HC, Carter BJ, Depelteau JS, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D10Rat136, D10Rat135 | 10q32.1-10q32.3 | 17q21.3-q25.3 | |
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Mamm Genome | Jones HC, Depelteau JS, Carter BJ, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D10Rat136, D10Rat135 | 10q32.1-10q32.3 | 17q21.3-q25.3 | |
Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat. | Jones HC, Carter BJ, Depelteau JS, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D11Arb2, D11Rat46 | 11q23 | 3q27-28, 22q11.21, 10p12.2 | |
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Mamm Genome | Jones HC, Depelteau JS, Carter BJ, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D11Arb2, D11Rat46 | 11q23 | 3q27-28, 22q11.21, 10p12.2 | |
Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat. | Jones HC, Carter BJ, Depelteau JS, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D17Mit4, D17Rat154 | 17q12.1 | 1q43, 10p11.21-p13 | |
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Mamm Genome | Jones HC, Depelteau JS, Carter BJ, et al. | 2001 | Rat | HTX | Congenital | Quantitative Trait Locus | D17Mit4, D17Rat154 | 17q12.1 | 1q43, 10p11.21-p13 | |
Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. | Tullio AN, Bridgman PC, Tresser NJ, et al. | 2001 | Mouse | C5BL/6J | Congenital | Autosomal Recessive | Nmhc-b | 11 | 17q13 | MYH10 |
Hydrocephalus in mice following X-irradiation at early gestational stage: possibly due to persistent deceleration of cell proliferation | Aolad HM, Inouye M, Darmanto W, et al. | 2000 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Late onset X-linked hydrocephalus with normal cerebrospinal fluid pressure. | Katsuragi S, Teraoka K, Ikegami K, et al. | 2000 | Human | n/a | Adult Onset | X-linked | Unknown | x | x | |
Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice | S L Brody, X H Yan, M K Wuerffel, S K Song, S D Shapiro | 2000 | Mouse | C57BL/6 background | hydrocephalus associated with PCD | Autosomal Dominant | Foxj1 | 11 | 17q25.1 | FOXJ1 |
Congenital hydrocephalus internus and aqueduct stenosis: aetiology and implications for genetic counselling. | Haverkamp F, Wolfle J, Aretz M, et al. | 1999 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Familial hydrocephalus. | Chalmers RM, Andreae L, Wood NW, et al. | 1999 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Autosomal recessive hydrocephalus due to congenital stenosis of the aqueduct of sylvius. | Hamada H, Watanabe H, Sugimoto M, et al. | 1999 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Sibs with Axenfeld-Rieger anomaly, hydrocephalus, and leptomeningeal calcifications: a new autosomal recessive syndrome? | Moog U, Bleeker-Wagemakers EM, Crobach P, et al. | 1998 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Familial congenital hydrocephalus and aqueduct stenosis with probably autosomal dominant inheritance and variable expression. | Verhagen WI, Bartels RH, Fransen E, et al. | 1998 | Human | n/a | Congenital | Autosomal Dominant | Unknown | 8q12.2-21.2 or unknown | ||
The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. | Kume T, Deng KY, Winfrey V, et al. | 1998 | Mouse | ch | Congenital | Autosomal Recessive | Mf1 | 13 | 6p25 | FREAC-3 |
Autosomal recessive diseases among Palestinian Arabs. | Zlotogora J | 1997 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Genetic disorders among Palestinian Arabs. 2. Hydrocephalus and neural tube defects. | Zlotogora J | 1997 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Bilateral sensorineural deafness and hydrocephalus due to foramen of Monro obstruction in sibs: a newly described autosomal recessive disorder. | Chudley AE, McCullough C, McCullough DW | 1997 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Hydrocephalus in the Otx2+/− mutant mouse. | Makiyama Y, Shoji S, Mizusawa H | 1997 | Mouse | C57BL/CBA | Congenital | Autosomal Dominant | Otx2 | 14 | 14q21-q22 | OTX2 |
Autosomal recessive hydrocephalus with aqueductal stenosis. | Castro-Gago M, Alonso A, Eiris-Punal J | 1996 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m404/m491 | Congenital | Autosomal Recessive | apo | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m404/m491 | Congenital | Autosomal Recessive | apo | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m409/m432 | Congenital | Autosomal Recessive | cudak | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m409/m432 | Congenital | Autosomal Recessive | cudak | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m691 | Congenital | Autosomal Recessive | eagle | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m691 | Congenital | Autosomal Recessive | eagle | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m591 | Congenital | Autosomal Recessive | endeavor | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m591 | Congenital | Autosomal Recessive | endeavor | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m584 | Congenital | Autosomal Recessive | enterprise | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m584 | Congenital | Autosomal Recessive | enterprise | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m492/m510 | Congenital | Autosomal Recessive | galileo | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m492/m510 | Congenital | Autosomal Recessive | galileo | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m445/m585/m700 | Congenital | Autosomal Recessive | gumowy | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m445/m585/m700 | Congenital | Autosomal Recessive | gumowy | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m727 | Congenital | Autosomal Recessive | hubble | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m727 | Congenital | Autosomal Recessive | hubble | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m221/m470/m680 | Congenital | Autosomal Recessive | interrail | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m221/m470/m680 | Congenital | Autosomal Recessive | interrail | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m733 | Congenital | Autosomal Recessive | kepler | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m733 | Congenital | Autosomal Recessive | kepler | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m728 | Congenital | Autosomal Recessive | neil | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m728 | Congenital | Autosomal Recessive | neil | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m481 | Congenital | Autosomal Recessive | pan twardowski | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m481 | Congenital | Autosomal Recessive | pan twardowski | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m172/m476 | Congenital | Autosomal Recessive | uchu hikoushi | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m172/m476 | Congenital | Autosomal Recessive | uchu hikoushi | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m766 | Congenital | Autosomal Recessive | voyager | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m766 | Congenital | Autosomal Recessive | voyager | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m331 | Congenital | Autosomal Recessive | viking | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m331 | Congenital | Autosomal Recessive | viking | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m479/m627 | Congenital | Autosomal Recessive | yura | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m479/m627 | Congenital | Autosomal Recessive | yura | unknown | ||
Mutations affecting neural survival in the zebrafish Danio rerio. | Abdelilah S, Mountcastle-Shah E, Harvey M, et al. | 1996 | Zebrafish | m111/m307/m15/m97 | Congenital | Autosomal Recessive | zezem | unknown | ||
A genetic screen for mutations affecting embryogenesis in zebrafish. | Driever W, Solnica-Krezel L, Schier AF, et al. | 1996 | Zebrafish | m111/m307/m15/m97 | Congenital | Autosomal Recessive | zezem | unknown | ||
Familial hydrocephalus of prenatal onset. | Zlotogora J, Sagi M, Cohen T | 1994 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
A proposed new contiguous gene syndrome on 8q consists of Branchio-Oto-Renal (BOR) syndrome, Duane syndrome, a dominant form of hydrocephalus and trapeze aplasia; implications for the mapping of the BOR gene. | Vincent C, Kalatzis V, Compain S, et al. | 1994 | Human | n/a | Congenital | Autosomal Dominant | Unknown | 8q12.2-21.2 or unknown | ||
A missense mutation confirms the L1 defect in X-linked hydrocephalus (HSAS). | Jouet M, Rosenthal A, MacFarlane J, et al. | 1993 | Human | n/a | Congenital | X-linked | L1cam | x | x | L1CAM |
Autosomal recessive hydrocephalus with third ventricle obstruction. | Chow CW, McKelvie PA, Anderson RM, et al | 1990 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Fetal growth retardation, hydrocephalus, hypoplastic multilobed lungs, and other anomalies in 4 sibs. | Game K, Friedman JM, Paradice B, et al | 1989 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Autosomal recessive nonsyndromal hydrocephalus. | Teebi AS, Naguib KK | 1988 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Familial occurrence of idiopathic normal-pressure hydrocephalus. | Portenoy RK, Berger A, Gross E | 1984 | Human | n/a | Adult Onset | Autosomal Dominant | NPH | unknown | ||
Congenital hydrocephalus revealed in the inbred rat, LEW/Jms. | Sasaki S, Goto H, Nagano H, et al. | 1983 | Rat | LEW/Jms | Congenital | Autosomal Recessive, Quantitative Trait Locus | uknown | unknown | ||
The pathophysiology and morphology of murine hydrocephalus in Hy-3 and Ch mutants. | Raimondi AJ, Bailey OT, McLone DG, et al. | 1973 | Mouse | hy3 | Congenital | Autosomal Recessive | Hydin | 8 | 16q22.2 | HYDIN |
New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. | Borit A, Sidman RL | 1972 | Mouse | STOCK tb | Congenital | Autosomal Recessive | oh | unknown | ||
Obstructive hydrocephalus. | Dickie M | 1968 | Mouse | STOCK tb | Congenital | Autosomal Recessive | oh | unknown | ||
Consecutive Hydrocephalus: Report of 2 Cases. | Abdul-Karim R, Iliya F, Iskandar G | 1964 | Human | n/a | Congenital | Autosomal Recessive | Unknown | unknown | ||
Two new mutant genes in the house mouse. | Gruneberg H | 1943 | Mouse | hy3 | Congenital | Autosomal Recessive | Hydin | 8 | 16q22.2 | HYDIN |
Two hereditary types of hydrocephalus in the house mouse (Mus musculus). | Clark F | 1935 | Mouse | hy2 | Congenital | Autosomal Recessive | unknown | unknown | ||
Anatomical basis of a hereditary hydrocephalus in the house mouse | Clark F | 1934 | Mouse | hy1 | Congenital | Autosomal Recessive | unknown | unknown | ||
Eine neue Mutation der Hausmaus: “hydrocephalus”. | Zimmermann K | 1933 | Mouse | hy2 | Congenital | Autosomal Recessive | unknown | unknown | ||
Hydrocephalus, a hereditary character in the house mouse. | Clark F | 1932 | Mouse | hy1 | Congenital | Autosomal Recessive | unknown | unknown |
Animal Models - Kaolin
Title
|
Author | Year | Species | Strain | Site of Injection | Solution Amount | Age or Weight at Injection | Clinical Form | Notes |
---|---|---|---|---|---|---|---|---|---|
Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration | Tito Vivas-Buitrago, Armelle Lokossou , Ignacio Jusue-Torres, Gabriel Pinilla-Monsalve, Ari M. Blitz, Daniel A. Herzka, Jamie Robison, Jiadi Xu, Hugo Guerrero-Cazares, Susumu Mori, Alfredo Quinones-Hinojosa, Olivier Baledent, Daniele Rigamonti | 2019 | Rat | Sprague-Dawley | Subarachnoid Space | 30 uL of 25% of kaolin in saline | adult | Chronic Communicating | injected into the subarachnoid space over the cerebral convexities bilaterally (15 uL on each side at a rate of 2 mL/second with a Harvard micropump) |
A Rat Model of Neurocysticercosis-Induced Hydrocephalus: Chronic Progressive Hydrocephalus With Mild Clinical Impairment | Pedro Tadao Hamamoto Filho, Marcelo Ortolani Fogaroli, Marcelo Augusto Chiantelli Oliveira, Cristiano Claudino Oliveira, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Luiz Carlos Vulcano, Rodrigo Bazan, Marco Antônio Zanini | 2019 | Rat | Wistar | Cisterna Magna | 0.02 mL of a 25% kaolin suspension | 100-200 g | ||
Comprehensive Analysis of Differentially Expressed Profiles of Long Non-Coding RNAs and Messenger RNAs in Kaolin-Induced Hydrocephalus | Yan-Hui Shi, Xin-Wei He, Feng-Di Liu, Yi-Sheng Liu, Yue Hu, Liang Shu, Guo-Hong Cui, Rong Zhao, Lei Zhao, Jing-Jing Su , Jian-Ren Liu | 2019 | Mouse | C57BL/6 | Cisterna Magna | 10 uL of 25% sterile kaolin suspension | 25-30 g | ||
Light Microscopic Evaluation of Acute and Chronic Hypophyseal Endocrinopathy in a Kaolin-Induced Hydrocephalus Model | Raziye Handan Nurhat, Hakan Sabuncuoglu, Burak Kazanci, Ferda Topal Celikkan, Bizden Sabuncuoglu | 2019 | Rat | Sprague-Dawley | Cisterna Magna | 0.1 ml kaolin suspension (250 mg/mL) | 8 weeks | acute and chronic hydrocephalus groups (kept alive for 4 and 8 weeks respectively post injection) | |
Erythropoietin Protects the Subventricular Zone and Inhibits Reactive Astrogliosis in Kaolin-Induced Hydrocephalic Rats | Wihasto Suryaningtyas, Muhammad Arifin, Fedik Abdul Rantam, Abdul Hafid Bajamal, Yoes Prijatna Dahlan, I Dewa Gede Ugrasena, Sri Maliawan | 2019 | Rat | Sprague-Dawley | Cisterna Magna | 0.05 ml of 20% kaolin suspension | 10 weeks | ||
Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats | Marcelo Volpon Santos, Luiza da Silva Lopes, Hélio Rubens Machado, Ricardo Santos de Oliveira | 2019 | Rat | Wistar | Cisterna Magna | 0.04 mL of 15% kaolin suspended in distilled water, previously sterilized at 60°C. | 7 PN | Obstructive | |
Intracisternal BioGlue injection in the fetal lamb: a novel model for creation of obstructive congenital hydrocephalus without additional chemically induced neuroinflammation | Marc Oria, Soner Duru, Federico Scorletti, Fernando Vuletin, Jose L Encinas, Laura Correa-Martín, Kenan Bakri, Helen N Jones, Francisco M Sanchez-Margallo, Jose L Peiro | 2019 | Lamb | n/a | Cisterna Magna | 1 mL of 2% (20 mg/ml) kaolin | 85-90 gestational age | Obstructive | 2.0 mL BioGlue into cisterna magna showed to be more effective for inducing hydrocephalus |
Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats With Kaolin-Induced Hydrocephalus | Mehmet Turgut, Meral Baka, Yiğit Uyanıkgil | 2018 | Rat | Swiss Albino | Cisterna Magna | 0.05 mL of sterile kaolin suspension | 14 PN | ||
Memantine Treatment of Juvenile Rats With Kaolin-Induced Hydrocephalus | Domenico L Di Curzio, Gurjit Nagra, Xiaoyan Mao, Marc R Del Bigio | 2018 | Rat | Long Evans | Cisterna Magna | 0.2 mL of 20% sterile kaolin suspension (250 mg/mL in 0.9% saline) | 21 PN | ||
Parenchymal Pressure Inconsistency in Different Brain Areas After Kaolin Injection Into the Subarachnoid Space of Neonatal Rats | Murat Vural, T Erhan Cosan, Kubilay Uzuner, Nilufer Erkasap, Didem Cosan, Cengiz Bal | 2018 | Rat | Sprague-Dawley | Subarachnoid Space | 0.03 ml of kaolin (200 mg/ml) | 6-7.5 g at 2-3 PN | 2 kaolin groups: right frontal region and right parietal region of subarachnoid space | |
Erythropoietin-mediated Activation of aquaporin-4 Channel for the Treatment of Experimental Hydrocephalus | M Rizwan Siddiqui, Furqan Attar, Vineet Mohanty, Kwang Sik Kim, C Shekhar Mayanil, Tadanori Tomita | 2018 | Rat | Sprague-Dawley | Cisterna Magna | 50 μl, 10 mg/ml in sterile saline | 20-22 g at 14 PN | Obstructive | |
Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model | Tito Vivas-Buitrago, Gabriel Pinilla-Monsalve, Ignacio Jusué-Torres, Kumiko Oishi, Jamie Robison, Joshua A Crawford, Mikhail Pletnikov, Jiadi Xu, Olivier Baledént, Armelle Lokossou, Alice L Hung, Ari M Blitz, Jennifer Lu, Daniel A Herzka, Hugo Guerrero-Cazares, Kenichi Oishi, Susumu Mori, Alfredo Quiñones-Hinojosa, Daniele Rigamonti | 2018 | Rat | Sprague-Dawley | Subarachnoid Space | sterile suspension of 25% kaolin in saline was injected at a rate of 2 μL/second for 15 seconds | 250 g at 12 weeks | Chronic Communicating | |
Acupuncture at ST36 Exerts Neuroprotective Effects via Inhibition of Reactive Astrogliosis in Infantile Rats With Hydrocephalus | Jacqueline Atsuko Tida, Carlos Henrique Rocha Catalão, Camila Araújo Bernardino Garcia, Antônio Carlos Dos Santos, Carlos Ernesto Garrido Salmon, Luiza da Silva Lopes | 2018 | Rat | Wistar | Cisterna Magna | 0.04mL of 20% kaolin suspension in distilled water was injected | 7 PN | ||
Hyperbaric Oxygen Therapy Reduces Astrogliosis and Helps to Recovery Brain Damage in Hydrocephalic Young Rats | Stephanya Covas da Silva, Omar Feres, Pâmella da Silva Beggiora, Hélio Rubens Machado, Rafael Menezes-Reis, João Eduardo Araújo, Ricardo Andrade Brandão, Luiza da Silva Lopes | 2018 | Rat | Wistar | Cisterna Magna | 04 ml of sterile kaolin suspension, diluted to 10% in distilled water | 7 PN | ||
Normal Macromolecular Clearance Out of the Ventricles Is Delayed in Hydrocephalus | Satish Krishnamurthy, Jie Li, Yimin Shen, Thomas M Duncan, Kenneth A Jenrow, E Mark Haacke | 2018 | Rat | Sprague-Dawley | Basal Cisterns | 30 μl sterile suspension of 25% kaolin in saline | 220-250 g | Communicating | |
Normal Macromolecular Clearance Out of the Ventricles Is Delayed in Hydrocephalus | Satish Krishnamurthy, Jie Li, Yimin Shen, Thomas M Duncan, Kenneth A Jenrow, E Mark Haacke | 2018 | Rat | Sprague-Dawley | Cisterna Magna | 30 μl sterile suspension of 25% kaolin in saline | 220-250 g | Obstructive | |
Comparative study of intracisternal kaolin injection techniques to induce congenital hydrocephalus in fetal lamb |
Soner Duru, Marc Oria, Silvia Arevalo, Carlota Rodo, Laura Correa, Fernando Vuletin, Francisco Sanchez-Margallo, Jose L. Peiro | 2018 | Lamb | n/a | Cisterna Magna | 1 mL of kaolin (2% in saline) suspension | 85-90 gestational age | Open uterine and tran uterine techniques found to be more effective than transabdominal ultrasound-guided | |
Hydrocephalus Compacted Cortex and Hippocampus and Altered Their Output Neurons in Association With Spatial Learning and Memory Deficits in Rats | Li-Jin Chen, Yueh-Jan Wang, Jeng-Rung Chen, Guo-Fang Tseng | 2017 | Rat | Sprague-Dawley | Cisterna Magna | 0.06 mL of sterile kaolin suspension (250 mg/mL in 0.9% saline) | 45-60 g at 21 PN | PHH or Post Infectious | |
Effects of Melatonin on the Cerebellum of Infant Rat Following Kaolin-Induced Hydrocephalus: A Histochemical and Immunohistochemical Study | Yiğit Uyanıkgil, Mehmet Turgut & Meral Baka | 2017 | Rat | Wistar | Cisterna Magna | 0.05 ml of a sterile kaolin | 14 PN | albino wistar rat pups | |
Edaravone Reduces Astrogliosis and Apoptosis in Young Rats With Kaolin-Induced Hydrocephalus | Camila Araújo Bernardino Garcia, Carlos Henrique Rocha Catalão, Hélio Rubens Machado, Ivair Matias Júnior, Thais Helena Romeiro, José Eduardo Peixoto-Santos, Marcelo Volpon Santos, Luiza da Silva Lopes | 2017 | Rat | Wistar | Cisterna Magna | 0.04 ml of kaolin diluted to 20% in distilled water | 7 PN | ||
Intraventricular Administration of Urokinase as a Novel Therapeutic Approach for Communicating Hydrocephalus | Zhou Feng, Qiang Tan, Jun Tang, Lin Li, Yihao Tao, Yujie Chen, Yunfeng Yang, Chunxia Luo, Hua Feng, Gang Zhu, Qianwei Chen, Zhi Chen | 2017 | Rat | Sprague-Dawley | Basal Cisterns | 30 uL of sterile 25% kaolin suspension | 250-300 g | Communicating | |
Development of Acute Hydrocephalus Does Not Change Brain Tissue Mechanical Properties in Adult Rats, but in Juvenile Rats | Alice C Pong, Lauriane Jugé, Lynne E Bilston, Shaokoon Cheng | 2017 | Rat | Sprague-Dawley | Cisterna Magna | 60 μL of a suspension of kaolin 25% w/v in 0.9% saline | 10 weeks | ||
Environmental Enrichment Reduces Brain Damage in Hydrocephalic Immature Rats | Carlos Henrique Rocha Catalão, Glaucia Yuri Shimizu, Jacqueline Atsuko Tida, Camila Araújo Bernardino Garcia, Antonio Carlos Dos Santos, Carlos Ernesto Garrido Salmon, Maria José Alves Rocha, Luiza da Silva Lopes | 2017 | Rat | Wistar | Cisterna Magna | 0.04 ml of 20% kaolin suspension in distilled water | 15-30 g | ||
Changes in Rat Brain Tissue Microstructure and Stiffness during the Development of Experimental Obstructive Hydrocephalus | Lauriane Jugé, Alice C. Pong, Andre Bongers, Ralph Sinkus, Lynne E. Bilston, and Shaokoon Cheng | 2016 | Rat | Sprague-Dawley | Cisterna Magna | 30 uL of suspension of kaolin 25% w/v in 0.9% saline at the rate of 6 μL/s | 21 PN | Obstructive Inflammatory | |
Magnesium Sulfate Treatment for Juvenile Ferrets Following Induction of Hydrocephalus With Kaolin | Domenico L Di Curzio, Emily Turner-Brannen, Xiaoyan Mao, Marc R Del Bigio | 2016 | Ferret | Pigmented Sable | Cisterna Magna | 0.2 mL of 20 % sterile kaolin suspension (250 mg/mL in 0.9 % saline) | 69-93 g at 15 PN | ||
Diffusion Tensor Imaging With Direct Cytopathological Validation: Characterisation of Decorin Treatment in Experimental Juvenile Communicating Hydrocephalus | Anuriti Aojula, Hannah Botfield, James Patterson McAllister II, Ana Maria Gonzalez, Osama Abdullah, Ann Logan & Alexandra Sinclair | 2016 | Rat | Sprague-Dawley | Basal Cisterns | 30 µl of 20 % kaolin solution (200 mg/ml in 0.9 % sterile saline) | 21 PN | Communicating | |
The retrograde ventriculosinusal shunt in an animal experimental model of hydrocephalus | Fernando Campos Gomes Pinto, Rodrigo Becco, Eduardo Joaquim Lopes Alho, Luiz Francisco Poli-de-Figueiredo, Podalyro Amaral de Souza, Matheus Fernandes de Oliveira, Manoel Jacobsen Teixeira | 2016 | Dog | Mongrel | Cisterna Magna | 3 mL of sterile kaolin solution (0.3 mg/mL) | 13-15 kg | ||
Ventricular-subcutaneous Shunt for the Treatment of Experimental Hydrocephalus in Young Rats: Technical Note | Marcelo Volpon Santos, Camila Araujo Bernardino Garcia, Evelise Oliveira Jardini, Thais Helena Romeiro, Luiza da Silva Lopes, Hélio Rubens Machado & Ricardo Santos de Oliveira | 2016 | Rat | Wistar | Cisterna Magna | 0.04 ml of kaolin diluted to 20 % in distilled water | 7 PN | ||
Hydrocephalus induced via intraventricular kaolin injection in adult rats | Zhang Shaolin, Wang Zhanxiang, Xu Hao, Zhang Feifei, Huang Caiquan, Chen Donghan, Bao Jianfeng, Liu Feng, Shen Shanghang | 2015 | Rat | Sprague-Dawley | Lateral Ventricle | 30 μl sterile suspension of 3% kaolin in saline | 240-260 g | Communicating | |
Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP | Gerald D Silverberg, Miles C Miller, Crissey L Pascale, Ilias N Caralopoulos, Yuksel Agca, Cansu Agca and Edward G Stopa | 2015 | Rat | APP 21 transgenic rats (tgAPP21) | Cisterna Magna | kaolin (aluminum silicate 0.9%) | 6-12 month | rats express high levels of human APP and naturally overproduce Aβ40, but not Aβ42. The tgAPP21 rats were produced from inbred Fischer 344 rats that express human APP driven by the ubiquitin-C promoter. They were generated via lentiviral vector infection of the Fischer 344 zygotes | |
CSF flow pathways through the ventricle-cistern interfaces in kaolin-induced hydrocephalus rats-laboratoryinvestigation. | Yoon JS, Nam TK, Kwon JT, Park SW, Park YS. | 2015 | Rat | Sprague-Dawley | Cisterna Magna | 100 μL of 20 % kaolin insterted at the rate of about 6 μL/s | 280-300 g | Chronic Obstructive | |
Recording of intracranial pressure in conscious rats via telemetry. | Guild SJ, McBryde FD, Malpas SC. | 2015 | Rat | Wistar | Cisterna Magna | 30 ul of a 25% Kaolin suspension in saline | 297-394 g | ||
Inhibition of Wnt/β-catenin Signal Is Alleviated Reactive Gliosis in Rats With Hydrocephalus | Hao Xu, Bin Xu, ZhanXiang Wang, GuoWei Tan, ShangHang Shen | 2015 | Rat | Sprague-Dawley | Lateral Ventricle | 30-μl sterile suspension of 3 % kaolin (ultrasonic emulsification about 15 min) in saline | 240-260 g | ||
Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging | Ramin Eskandari & Osama Abdullah & CameronMason & Kelley E. Lloyd & Amanda N. Oeschle & James P. McAllister II | 2014 | Feline | Cisterna Magna | 25% sterile kaolin | 2 weeks | Obstructive | ||
Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the model of experimental acute hydrocephalus in rabbits | Maxim A. Shevtsov & Konstantin A. Senkevich & Alexander V. Kim & Kseniia A. Gerasimova & Tatyana N. Trofimova & Galina V. Kataeva & Sviatoslav V. Medvedev & Olga I. Smirnova & Zhanna I. Savintseva & Marina G. Martynova & Olga A. Bystrova & Emil Pitkin & Galina Y. Yukina & William A. Khachatryan | 2014 | Rabbit | New Zealand | Lateral Ventricle | 0.4 ml of 30 % kaolin solution | 4.5-5.5 kg | Acute Obstructive | |
Inhibition of Wnt/β-catenin signal is alleviated reactive gliosis in rats with hydrocephalus | Hao Xu & Bin Xu & ZhanXiang Wang & GuoWei Tan & ShangHang Shen | 2014 | Rat | Sprague-Dawley | Lateral Ventricle | 30-μl sterile suspension of 3 % kaolin in saline | 240-260 g | ||
Pre- and Postshunting Magnetization Transfer Ratios Are in Accordance with Neurological and Behavioral Changes in Hydrocephalic Immature Rats | Carlos Henrique, Rocha Catalão Diego Augusto, Leme Correa, Camila Araújo, Bernardino Garci, Antonio Carlos dos Santos, Carlos Ernesto, Garrido Salmon, Maria José, Alves Rocha, Luiza da Silva Lopes | 2014 | Rat | Wistar | Dorsal Edge of the Foramen Magnum and the First Cervical Vertebra | 40 μl of a 20% sterile kaolin suspension in distilled water | 7 PN | ||
Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus | Domenico L Di Curzio, Emily Turner-Brannen and Marc R Del Bigio | 2014 | Rat | Sprague-Dawley | Cisterna Magna | sterile suspension of kaolin (aluminum silicate, 250 mg/mL; Sigma, St. Louis MO) in 0.9% normal saline (0.04 mL) | 21-23 PN | ||
Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus | Domenico L Di Curzio, Emily Turner-Brannen and Marc R Del Bigio | 2014 | Rat | Long Evans | Cisterna Magna | sterile suspension of kaolin (aluminum silicate, 250 mg/mL) in 0.9% normal saline (0.04 mL) | 21-23 PN | ||
Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats. | Michael T. Williams, Amanda A. Braun, Robyn Amos-Kroohs, James P. McAllister II, Diana M. Lindquist, Francesco T. Mangano, Charles V. Vorhees, Weihong Yuan | 2014 | Rat | Sprague-Dawley | Cisterna Magna | 30-50 μl kaolin (25% w/v in sterile saline) | 21 PN | ||
Camellia sinensis neuroprotective role in experimentally induced hydrocephalus in Wistar rats | Carlos Henrique Rocha Catalão & Diego Augusto Leme Correa & Samuel Takashi Saito & Luiza da Silva Lopes | 2014 | Rat | Wistar | Dorsal Edge of the Foramen Magnum and the First Cervical Vertebra | 0.04 ml of 20 % kaolin (aluminum silicate; Sigma, St. Louis MO) suspension in distilled water was injected. | 7 PN | ||
Decorin prevents the development of juvenile communicating hydrocephalus | Botfield H, Gonzalez AM, Abdullah O, Skjolding AD, Berry M, McAllister JP 2nd, Logan A. | 2013 | Rat | Sprague-Dawley | Basal Cisterns | 30 μl of 20% kaolin | 3 weeks | Communicating | |
Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus | Miles G Johnston, Marc R Del Bigio, James M Drake, Dianna Armstrong, Domenico L Di Curzio and Jeff Bertrand | 2013 | Sheep | Ovis Aries, Dorset breed | Cisterna Magna | 3 ml of a 25% suspension | |||
Reduced subventricular zone proliferation and white matter damage in juvenile ferrets with kaolin-induced hydrocephalus | Domenico L. Di Curzio, Richard J. Buist, Marc R. Del Bigio | 2013 | Ferret | Pigmented Sable | Cisterna Magna | 0.2 mL of 20% sterile kaolin suspension (250 mg/mL in 0.9% saline) | 13-14 PN | ||
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus | Hao Xu, M.M., Zhanxiang Wang, M.D., Shaolin Zhang, M.M., Guowei Tan, M.M., and Hongwei Zhu, M.D | 2013 | Rat | Sprague-Dawley | Lateral Ventricle | 30-ml sterile suspension of 3% kaolin (ultrasonic emulsification about 15 minutes) in saline | 240-260 g | Communicating | |
Expression of HGF, MMP-9 and TGF-β1 in the CSF and cerebral tissue of adult rats with hydrocephalus | Shaolin Zhang, Donghan Chen, Caiquan Huang, Jianfeng Bao, and Zhanxiang Wang | 2013 | Rat | Sprague-Dawley | Lateral Ventricle | 30-μl sterile suspension of 3% kaolin in saline | 240–260 g | ||
Differences in distribution and regulation of astrocytic aquaporin-4 in human and rat hydrocephalic brain. | Skjolding AD, Holst AV, Broholm H, Laursen H, Juhler M. | 2013 | Rat | Sprague-Dawley | Cisterna Magna | 0.050 ml of sterile kaolin suspension (0.250 mg/mL Ringer’s lactate solution (1.4 mM Ca2+, 4 mM K+, 130 mM Na+, 109 mM Cl-, 28 mM lactate) | 8 weeks | ||
Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits. | Köktürk S, Ceylan S, Etus V, Yasa N, Ceylan S. | 2013 | Rabbit | New Zealand | Cisterna Magna | 0.5 mL (500 mg/mL in 0.09 % (w/v) NaCl) kaolin suspension | 4-5 months | ||
A Multisensor Implant for Continuous Monitoring of Intracranial Pressure Dynamics | Stefanie Jetzki, Member, IEEE, Martin Weinzierl, Inga Krause, Sebastian Hahne, Hubertus Rehbaum, Michael Kiausch, Ivanna Kozubek, Carmen Hellenbroich, Markus Oertel, Marian Walter, Member, IEEE, and Steffen Leonhardt, Senior Member, IEEE | 2012 | Pig | Cisterna Magna | similar to bernard williams (look below) | ||||
Morphological and Morphometric Analysis of the Hippocampus in Wistar Rats with Experimental Hydrocephalus | Meira Taveira K.V., Carraro K.T., Rocha Catalão C.H., da Silva Lopes L | 2012 | Rat | Wistar | Cisterna Magna | 20% kaolin suspension | 7 PN | ||
0.1T magnetic resonance image in the study of experimental hydrocephalus in rats. Accuracy of the method in the measurements of the ventricular size | Castro SC, Machado HR, Catalão CH, Siqueira BA, Simões AL, Lachat JJ, Lopes Lda S. | 2012 | Rat | Wistar | Cisterna Magna | 0.04ml of 20% sterile kaolin suspension diluted in distilled water | 7 PN | ||
The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats | Olopade FE, Shokunbi MT, Sirén AL. | 2012 | Rat | Not Specified | Cisterna Magna | sterile kaolin suspension, 0.02 ml (250 mg/ml in distilled water) with a 27 gauge needle | 3 weeks | ||
Cerebrospinal fluid volume measurements in hydrocephalic rats | Basati S, Desai B, Alaraj A, Charbel F, Linninger A. | 2012 | Rat | Sprague-Dawley | Cisterna Magna | 20 μl of 25% w/v sterile kaolin suspension | 3 weeks | ||
Intracranial biomechanics of acute experimental hydrocephalus in live rats. | Shulyakov AV, Buist RJ, Del Bigio MR. | 2012 | Rat | Sprague-Dawley | Cisterna Magna | 0.02 mL of sterile kaolin suspension (200 mg/mL kaolin in 0.9% saline) | 56 PN | ||
Effect of delayed intermittent ventricular drainage on ventriculomegaly and neurological deficits in experimental neonatal hydrocephalus. | Eskandari R, Packer M, Burdett EC, McAllister JP 2nd. | 2012 | Feline | Cisterna Magna | 0.5 ml of 25 % kaolin suspension (12.5 g of kaolin powder in 50 ml of sterile water) | 2 weeks | |||
Reactive gliosis and neuroinflammation in rats with communicating hydrocephalus. | Xu H, Zhang SL, Tan GW, Zhu HW, Huang CQ, Zhang FF, Wang ZX | 2012 | Rat | Sprague-Dawley | Lateral Ventricle | 30 μl sterile suspension of 3% kaolin in saline | 240-260 g | ||
Cerebral white matter oxidation and nitrosylation in young rodents with kaolin-induced hydrocephalus. | Del Bigio MR, Khan OH, da Silva Lopes L, Juliet PA. | 2012 | Rat | Sprague-Dawley | Cisterna Magna | sterile kaolin (aluminum silicate) suspension (20Y30 KL of 20% suspension in 0.9% saline) | 7 PN | ||
Aquaporin-4 expression is not elevated in mild hydrocephalus. | Aghayev K, Bal E, Rahimli T, Mut M, Balci S, Vrionis F, Akalan N. | 2012 | Rat | Wistar-Hannover | Cisterna Magna | 5 μl 25% kaolin suspension in normal saline | 250–300 g | ||
Diffusion tensor imaging of white matter injury in a rat model of infantile hydrocephalus. | Yuan W, McAllister JP 2nd, Lindquist DM, Gill N, Holland SK, Henkel D, Rajagopal A, Mangano FT. | 2012 | Rat | Sprague-Dawley | Cisterna Magna | solution of kaolin (25% w/v in sterile saline) | 21 PN | ||
Neuroendoscopic surgery in empty ventricular system under continuous gas infusion experimental study of pressure changes and complications. | Turhan T, Aydın Ö, Ersahin Y | 2012 | Rabbit | New Zealand | Cisterna Magna | 200-mg/mL kaolin solution in normal saline, 0.5 mL | 2,500–3,100 g | ||
Morphometric analysis of the optic nerve in experimental hydrocephalus-induced rats | Aisengart B, Kajiwara JK, Veríssimo Meira K, da Silva Lopes L. | 2011 | Rat | Wistar | Suboccipital Percutaneous | 0.4 ml of a kaolin suspension diluted in distilled water of 20%. | 7 PN | ||
Changes caused by hydrocephalus, induced by kaolin, in the corpus callosum of adult dogs. | Cardoso EJ, Lachat JJ, Lopes LS, Santos AC, Colli BO. | 2011 | Dog | Canis Familiaris | Cisterna Magna | hydrated aluminum silicate / kaolin (30 g in 20 ml 0.9% saline in a dose of 50mg/kg) | 7-18 kg | ||
Reactive astrocytosis in feline neonatal hydrocephalus: acute, chronic, and shunt-induced changes. | Eskandari R, Harris CA, McAllister JP 2nd. | 2011 | Feline | Cisterna Magna | 50 μl of 25% kaolin solution in buffered saline | 10 PN | |||
Neuroprotective effect of memantine on hippocampal neurons in infantile rat hydrocephalus. | Cabuk B, Etus V, Bozkurt SU, Sav A, Ceylan S. | 2011 | Rat | Sprague-Dawley | Cisterna Magna | 0.05 ml of sterile kaolin suspension (250 mg/ml in 0.9% saline) | 3 weeks | ||
Magnetic resonance imaging indicators of blood-brain barrier and brain water changes in young rats with kaolin-induced hydrocephalus. | Del Bigio MR, Slobodian I, Schellenberg AE, Buist RJ, Kemp-Buors TL. | 2011 | Rat | Sprague-Dawley | Cisterna Magna | 0.025-0.030 ml of sterile kaolin suspension (250 mg/ml in 0.9% saline) | 4 weeks | ||
Tricarboxylic acid cycle activity measured by 13C magnetic resonance spectroscopy in rats subjected to thekaolin model of obstructed hydrocephalus. | Melø TM, Håberg AK, Risa Ø, Kondziella D, Henry PG, Sonnewald U. | 2011 | Rat | Sprague-Dawley | Cisterna Magna | 0.1 ml kaolin (4 g/ml 0.9% saline) | 2 months | ||
Anxiety responses and neurochemical changes in a kaolin-induced rat model of hydrocephalus | Hwang YS, Shim I, Chang JW. | 2011 | Rat | Sprague-Dawley | Cisterna Magna | 0.1 ml of 20% kaolin solution | 300–350 g | ||
Development of an acute obstructive hydrocephalus model in rats using N-butyl cyanoacrylate. | Park YS1, Park SW, Suk JS, Nam TK | 2011 | Rat | Sprague-Dawley | Cisterna Magna | 100 μL of 20% kaolin solution | 280-300 g | Acute Obstructive | |
Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. | Wang D, Nykanen M, Yang N, Winlaw D, North K, Verkman AS, Owler BK. | 2011 | Mouse | AQP1 KO | Cisterna Magna | 10 μL of 5% kaolin suspension in saline | 6-8 Weeks | ||
Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain | Skjolding AD, Rowland IJ, Søgaard LV, Praetorius J, Penkowa M, Juhler M. | 2010 | Rat | Sprague-Dawley | Cisterna Magna | 0.050 ml of sterile kaolin suspension (0.250 mg/mL Ringer’s lactate solution (1.4 mM Ca2+, 4 mM K+ , 130 mM Na+ , 109 mM Cl- , 28 mM lactate) | 8 weeks | ||
Reactive astrocytosis, microgliosis and inflammation in rats with neonatal hydrocephalus | Deren KE, Packer M, Forsyth J, Milash B, Abdullah OM, Hsu EW, McAllister JP 2nd | 2010 | Rat | Sprague-Dawley | Cisterna Magna | sterile suspension of 25% kaolin in saline | 1 PN | ||
The dynamics of brain and cerebrospinal fluid growth in normal versus hydrocephalic mice. | Mandell JG, Neuberger T, Drapaca CS, Webb AG, Schiff SJ. | 2010 | Mouse | C57BL/6 | Cisterna Magna | Ten microliters of sterilized kaolin solution, composed of 250 mg kaolin and 50 μl Magnevist contrast agent per milliliter of 0.9% saline | 14 PN | ||
Infliximab administration reduces neuronal apoptosis on the optic pathways in a rabbit hydrocephalus model: a preliminary report. | Kurt G, Cemil B, Borcek AO, Borcek P, Akyurek N, Sepici A, Ceviker N. | 2010 | Rabbit | New Zealand | Cisterna Magna | 0.1 to 0.2 ml of sterile kaolin suspension (250 mg/ml) | 5100-6200 g | ||
Elevated CSF outflow resistance associated with impaired lymphatic CSF absorption in a rat model of kaolin-induced communicating hydrocephalus. | Nagra G, Wagshul ME, Rashid S, Li J, McAllister JP 2nd, Johnston M. | 2010 | Rat | Sprague-Dawley | Basal Cisterns | 50-μL sterile suspension of 25% kaolin in saline | 234-287 g | Communicating | |
Amyloid and Tau accumulate in the brains of aged hydrocephalic rats. | Silverberg GD, Miller MC, Machan JT, Johanson CE, Caralopoulos IN, Pascale CL, Heile A, Klinge PM. | 2010 | Rat | Sprague-Dawley | Cisterna Magna | 0.03 ml kaolin suspension (aluminum silicate, diluted with 0.9% saline; 1:4) | 12 months | ||
Low-dose kaolin-induced feline hydrocephalus and feline ventriculostomy: an updated model. | Lollis SS, Hoopes PJ, Kane S, Paulsen K, Weaver J, Roberts DW. | 2009 | Feline | Cisterna Magna | 10 mg in 0.25 ml of sterile saline | 2.0–3.5 kg | |||
The behavioral change of locomotor activity in a kaolin-induced hydrocephalus rat model: evaluation of the effect on the dopaminergic system with progressive ventricle dilatation. | Hwang YS, Shim I, Chang JW. | 2009 | Rat | Sprague-Dawley | Cisterna Magna | 0.1 ml of 20% kaolin solution | 300-350 g | ||
Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus. | Deren KE, Forsyth J, Abdullah O, Hsu EW, Klinge PM, Silverberg GD, Johanson CE, McAllister JP 2nd. | 2009 | Rat | Sprague-Dawley | Cisterna Magna | 1.0 ml syringe containing 25% kaolin in sterile saline | 1 PN | ||
Characterization of juvenile and young adult mice following induction of hydrocephalus with kaolin. | Lopes Lda S, Slobodian I, Del Bigio MR. | 2009 | Mouse | CD1 | Cisterna Magna | 0.3 ml sterile kaolin suspension (in 0.9% saline) | 7 PN an 7-8 weeks | ||
Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. | Wagshul ME, McAllister JP, Rashid S, Li J, Egnor MR, Walker ML, Yu M, Smith SD, Zhang G, Chen JJ, Benveniste H. | 2009 | Rat | Sprague-Dawley | Basal Cisterns | 30-μl sterile suspension of 25% kaolin in saline, injected manually at about 6 μl/ sec) | ∼250 g | Chronic Communicating | |
Gray matter metabolism in acute and chronic hydrocephalus. | Kondziella D, Eyjolfsson EM, Saether O, Sonnewald U, Risa O. | 2009 | Rat | Sprague-Dawley | Cisterna Magna | 0.1 ml kaolin (4 g/ml 0.9% saline) | 2 months old, 200g | ||
Model-based estimation of ventricular deformation in the cat brain. | Liu F, Lollis SS, Ji S, Paulsen KD, Hartov A, Roberts DW. | 2009 | Feline | Cisterna Magna | 10– 50 mg mixed in sterile saline | adult | |||
The effect of N-methyl-D-aspartate receptor antagonist (memantine) on esophageal and gastric smooth muscle: functional investigation in a rat hydrocephalus model. | Bektaş AO, Tugay M, Tugay S, Göçmez SS, Etus V, Utkan T. | 2008 | Rat | Sprague-Dawley | Cisterna Magna | sterile suspension of 25% kaolin | 8 weeks | ||
Effect of hydrocephalus on rat brain extracellular compartment. | Del Bigio MR, Enno TL. | 2008 | Rat | Sprague-Dawley | Cisterna Magna | (250 mg/ml in 0.9% saline | 1 PN, 3 weeks, 10 weeks | ||
Communicating hydrocephalus in adult rats with kaolin obstruction of the basal cisterns or the cortical subarachnoid space. | Li J, McAllister JP 2nd, Shen Y, Wagshul ME, Miller JM, Egnor MR, Johnston MG, Haacke EM, Walker ML. | 2008 | Rat | Sprague-Dawley | Basal Cisterns | 30-μl sterile suspension of 25% kaolin in saline was injected at the rate of about 6 µl/s (Basal Cistern) or A sterile suspension of 25% kaolin (60 µl) in saline, or saline alone, was injected into the subarachnoid space at a rate of approximately 2 µl/s (cerebral convexities) | 220-270 g | Communicating | |
Alterations in the mechanical properties of bladder smooth muscle in hydrocephalus rat model. | Tugay M, Tugay S, Etuş V, Yazir Y, Utkan T. | 2008 | Rat | Sprague-Dawley | Cisterna Magna | 0.05 mL of sterile kaolin suspension (250 mg/mL in 0.9% NaCl) | 7 PN | ||
Impaired lymphatic cerebrospinal fluid absorption in a rat model of kaolin-induced communicatinghydrocephalus. | Nagra G, Li J, McAllister JP 2nd, Miller J, Wagshul M, Johnston M. | 2008 | Rat | Sprague-Dawley | Subarachnoid Space | 50-l sterile suspension of 25% kaolin in saline was injected at the rate of about 6 l/s. | 246.01 +/- 2.41 g | Communicating | With obstructions of the basal cistern or cerebral convexities |
Calcium antagonism in neonatal rats with kaolin-induced hydrocephalus. | Khan OH, McPhee LC, Moddemann LN, Del Bigio MR. | 2007 | Rat | Sprague-Dawley | Cisterna Magna | (0.02 mL of sterile suspension [250 mg/mL in 0.9% saline] | 1 PN | ||
Fragmentation of protein kinase N (PKN) in the hydrocephalic rat brain. | Okii N, Amano T, Seki T, Matsubayashi H, Mukai H, Ono Y, Kurisu K, Sakai N. | 2007 | Rat | Wistar | Cisterna Magna | 0.03 ml–0.05 ml of 5% kaolin solution | 250–300 g | ||
Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats. | Slobodian I, Krassioukov-Enns D, Del Bigio MR. | 2007 | Rat | Sprague-Dawley | Cisterna Magna | 30–35 µl sterile kaolin suspension (250 mg/mL in 0.9% saline) | 3 weeks | ||
Melatonin ameliorates blood-brain barrier permeability, glutathione, and nitric oxide levels in the choroid plexus of the infantile rats with kaolin-induced hydrocephalus. | Turgut M, Erdogan S, Ergin K, Serter M. | 2007 | Rat | Swiss Albino | Cisterna Magna | 0.05 ml of sterile kaolin suspension | 2 weeks | ||
The effect of hydrocephalus on lower esophageal sphincter smooth muscle reactivity: experimental study. | Etus V, Tugay M, Utkan T, Ceylan S, Gacar N. | 2007 | Rat | Sprague-Dawley | Cisterna Magna | 0.05 mL of sterile kaolin suspension (250 mg/mL in 0, 9% NaCl) | 7 PN | ||
A ferritin tracer study of compensatory spinal CSF outflow pathways in kaolin-induced hydrocephalus. | Voelz K, Kondziella D, von Rautenfeld DB, Brinker T, Lüdemann W. | 2007 | Rat | Lewis | Cisterna Magna | 0.1 ml kaolin (4 g/ml, 0.9% saline) | 250–450 g | ||
Neuronal damage in hydrocephalus and its restoration by shunt insertion in experimental hydrocephalus: a study involving the neurofilament-immunostaining method. | Aoyama Y, Kinoshita Y, Yokota A, Hamada T. | 2006 | Dog | Mongrel | Cisterna Magna | kaolin solution (200 mg/kg) | 1-2 months, 2.5-3 kg | ||
Aquaporin 4 changes in rat brain with severe hydrocephalus. | Mao X, Enno TL, Del Bigio MR. | 2006 | Rat | Sprague-Dawley | Cisterna Magna | 0.01 mL sterile kaolin suspension (250 mg/ mL in 0.9% saline) | 1 PN or 21 PN | ||
Preservation of functional architecture in visual cortex of cats with experimentally induced hydrocephalus. | Imamura K, Tanaka S, Ribot J, Kobayashi M, Yamamoto M, Nakadate K, Watanabe Y. | 2006 | Feline | Cisterna Magna | 50 uL of 25% kaolin | 1 week | |||
Brain damage in neonatal rats following kaolin induction of hydrocephalus. | Khan OH, Enno TL, Del Bigio MR. | 2006 | Rat | Sprague-Dawley | Cisterna Magna | Sterile kaolin suspension (0.02 ml; 250 mg/ml in 0.9% saline) | 1 PN | ||
Heavy water inhibiting the expression of transforming growth factor-beta1 and the development of kaolin-induced hydrocephalus in mice. | Hatta J, Hatta T, Moritake K, Otani H. | 2006 | Mouse | Jcl:ICR | Cisterna Magna | 5 ml of 2% aluminum silicate in distilled water | 10-12 Weeks | ||
Brain amyloid accumulates in aged rats with kaolin-induced hydrocephalus. | Klinge PM, Samii A, Niescken S, Brinker T, Silverberg GD. | 2006 | Rat | Sprague-Dawley | Subarachnoid Space | 0.2 ml kaolin suspension (aluminum silicate diluted with 0.9% saline; 1:4) | 2, 6, 10 Weeks | ||
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. | Bloch O, Auguste KI, Manley GT, Verkman AS. | 2006 | Mouse | AQP4 null | Cisterna Magna | 10 mL of a kaolin suspension (250 mg/ml in PBS) | 6-8 Weeks | Obstructive | |
Pressure gradients in the brain in an experimental model of hydrocephalus. | Penn RD, Lee MC, Linninger AA, Miesel K, Lu SN, Stylos L. | 2005 | Dog | Mongrel | Cisterna Magna | 800 mg of sterile kaolin in wate | adult | ||
[Effect of Ginkgo biloba extract on neuronal apoptosis in rabbit with kaolin-induced syringomyelia]. | Yang GF0, Wang LN, Yang LB, Zhang QJ. | 2005 | Rabbit | Chinese White | Cisterna Magna | 25% kaolin mixed with equal volume .6 ml |
Animal Models - Blood Products
Title
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Author | Year | Species | Strain | Product | Site of Injection | Solution Amount | Age or Weight at Injection | Clinical Form | Notes |
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Dexamethasone does not prevent hydrocephalus after severe intraventricular hemorrhage in newborn rats | Lee JH, Chang YS, Ahn SY, Sung SI, Park WS | 2018 | Rat | Sprague-Dawley | Maternal Whole Blood | Lateral Ventricles | 200 uL | 4 PN | IVH/PHH | 100 uL injected into each ventricle; coordinates: x = ±0.5, y = +1.0, z = +2.5 mm relative to the bregma |
Aquaporin 4 Silencing Aggravates Hydrocephalus Induced by Injection of Autologous Blood in Rats. | Guo J, Mi X, Zhan R, Li M, Wei L, Sun J | 2018 | Rat | Sprague-Dawley | Autologous Blood | Lateral Ventricles | 200 ul | 260-300 g at 12 weeks | IVH/PHH | right lateral ventricle; coordinates: 0.6 mm posterior, 1.6 mm lateral, 4.5 mm ventral to the bregma |
Subarachnoid hemorrhage – Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor) | Eugene V Golanov, Evgeniy I Bovshik, Kelvin K Wong, Robia G Pautler, Chase H Foster, Richard G Federley, Jonathan Y Zhang, James Mancuso, Stephen TC Wong, Gavin W Britz | 2018 | Mouse | Jax Mice | Endovascular Perforation | Internal Carotid Artery | 10-14 weeks | SAH/PHH | proline monofilament was inserted until it perforated the internal arotid artery to cause bleeding and mimic a stroke in the brain. | |
Dabigatran ameliorates post-haemorrhagic hydrocephalus development after Germinal Matrix haemorrhage in neonatal rat pups | Damon Klebe, Jerry J Flores, Devin W McBride, Paul R Krafft, William B Rolland, Tim Lekic, John H Zhang | 2017 | Rat | Clostridial Collagenase VII-S | Germinal Matrix | 0.3 U/uL infused at rate of 0.1 U/min, needle was left in place for 5 min before being removed at a rate of 1 mm/min | 12-15g at 7 PN | GMH/PHH | coordinates: 1.6 mm right lateral and 1.5 mm rostral relative to bregma, 2.8 mm below the dura | |
Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36 | Chen Q, Shi X, Tan Q, Feng Z, Wang Y, Yuan Q, Tao Y, Zhang J, Tan L, Zhu G, Feng H, Chen Z | 2017 | Rat | Sprague-Dawley | Autologous Blood | Right Caudate Nucleus | 200 uL | 250-350 g | IVH/PHH | |
Prolonged hydrocephalus induced by intraventricular hemorrhage in rats is reduced by curcumin therapy. | Qi Z, Zhang H, Fu C, Liu X, Chen B, Dang Y, Chen H, Liu L | 2017 | Rat | Sprague-Dawley | Autologous Blood | Lateral Ventricles | 200 uL | 280-380 g | IVH/PHH | right lateral ventricle; coordinates: 1 mm posterior, 3.5 mm ventral, and 1.5 mm lateral to the Bregma |
Cannabinoid receptor 2 activation restricts fibrosis and alleviates hydrocephalus after intraventricular hemorrhage. | Tan Q, Chen Q, Feng Z, Shi X, Tang J, Tao Y, Jiang B, Tan L, Feng H, Zhu G, Yang Y, Chen Z | 2017 | Rat | Sprague-Dawley | Autologous Blood | Lateral Ventricles | 200uL | 250-350 g | IVH/PHH | coordinates: 0.2 mm posterior and 2.2 mm lateral to the bregma, 5.0 mm below dura |
Pivotal Role of Brain-Derived Neurotrophic Factor Secreted by Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage in Newborn Rats. | Ahn SY, Chang YS, Sung DK, Sung SI, Ahn JY, Park WS. | 2017 | Rat | Sprague-Dawley | Maternal Whole Blood | Lateral Ventricles | 200uL | 4 days PN | IVH/PHH | 100 uL into each ventricle |
PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after Germinal Matrix hemorrhage in neonatal rats. | Flores JJ, Klebe D, Rolland WB, Lekic T, Krafft PR, Zhang JH | 2016 | Rat | Sprague-Dawley | Clostridial Collagenase VII-S | Germinal Matrix | 0.3 units in 1 μL was infused over a period of 3 min. Inserted and removed at rate of 1mm/min | 12-15 g at 7 PN | GMH/PHH | coordinates: 1.6 mm (rostral), 1.6 mm (right lateral) from bregma, and 2.8 mm (depth) from the dura |
Decorin alleviated chronic hydrocephalus via inhibiting TGF-β1/Smad/CTGF pathway after subarachnoid hemorrhage in rats. | Yan H, Chen Y, Li L, Jiang J, Wu G, Zuo Y, Zhang JH, Feng H, Yan X, Liu F | 2016 | Rat | Sprague-Dawley | Autologous Blood | Cisterna Magna | 0.5 mL | 160-180 g at 6 weeks | SAH/PHH | |
The Effect of Gender on Acute Hydrocephalus after Experimental Subarachnoid Hemorrhage. | Shishido H, Zhang H, Okubo S, Hua Y, Keep RF, Xi G | 2016 | Rat | Sprague-Dawley | Endovascular Perforation | Internal Carotid Artery | n/a | 250-350 g | SAH/PHH | |
Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage. | Tim Lekic, Jerry Flores, Damon Klebe, Desislava Doycheva, William B. Rolland, Jiping Tang, John H. Zhang | 2016 | Rat | Sprague-Dawley | Clostridial Collagenase VII-S | Right Basal Ganglion | 0.3 units infused at 0.25 uL/min, withdrawn at rate of 1mm.min | 14-19 g at 7 PN | GMH/PHH | |
Intranasal Osteopontin for Rodent Germinal Matrix Hemorrhage. | Jay Malaguit, Darlene Casel, Brandon Dixon, Desislava Doycheva, Jiping Tang, John H. Zhang, Tim Lekic | 2016 | Rat | Sprague-Dawley | Clostridial Collagenase VII-S | Right Basal Ganglion | 0.3 units infused at 0.25 uL/min, withdrawn at rate of 1mm.min | 14-19 g at 7 PN | GMH/PHH | |
Optimal Timing of Mesenchymal Stem Cell Therapy for Neonatal Intraventricular Hemorrhage. | Park WS, Sung SI, Ahn SY, Sung DK, Im GH, Yoo HS, Choi SJ, Chang YS | 2015 | Rat | Sprague-Dawley | Maternal Whole Blood | Lateral Ventricles | 200 uL | 4 PN | IVH/PHH | 100 uL into each ventricle; coordinates: x = ±0.5, y = +1.0, z = +2.5 mm relative to bregma |
Intracerebral Hematoma Contributes to Hydrocephalus After Intraventricular Hemorrhage via Aggravating Iron Accumulation | Chen 1, Tang J, Tan L, Guo J, Tao Y, Li L, Chen Y, Liu X, Zhang JH, Chen Z, Feng H. | 2015 | Rat | Sprague-Dawley | Autologous Blood | Right Caudate Nucleus | 200 uL | 250-350 g | IVH/PHH | coordinates: 0.2 mm posterior, 5.0 mm ventral, and 2.2 mm lateral to the bregma |
Optimal Route for Mesenchymal Stem Cells Transplantation after Severe Intraventricular Hemorrhage in Newborn Rats. | Ahn SY, Chang YS, Sung DK, Sung SI, Yoo HS, Im GH, Choi SJ, Park WS | 2015 | Rat | Sprague-Dawley | Maternal Whole Blood | Lateral Ventricles | 200 uL | 4 PN | IVH/PHH | 100 uL into each ventricle |
Effect of decompressive craniectomy on outcome following subarachnoid hemorrhage in mice. | Bühler D, Azghandi S, Schüller K, Plesnila N | 2015 | Mouse | C57BL/6 | Endovascular Perforation | Circle of Willis | n/a | 22-25 g | SAH/PHH | male mice used |
Chronic hydrocephalus and perihematomal tissue injury developed in a rat model of intracerebral hemorrhage with ventricular extension | Chen Q, Zhang J, Guo J, Tang J, Tao Y, Li L, Feng H, Chen Z | 2014 | Rat | Sprague-Dawley | Autologous Blood | Right Caudate Nucleus | 200 uL | 250-350 g | ICH/PHH | coordinates: 0.2 mm posterior and 2.2 mm lateral to the bregma, 5.0 mm below dura |
Role of Hemoglobin and Iron in Hydrocephalus After Neonatal Intraventricular Hemorrhage | Jennifer M Strahle, Thomas Garton, Ahmad A Bazzi, Harish Kilaru, Hugh J L Garton, Cormac O Maher, Karin M Muraszko, Richard F Keep, Guohua Xi | 2014 | Rat | Sprague-Dawley | Hemoglobin and Iron | Lateral Ventricles | 20 uL | 7 PN | IVH/PHH | right lateral ventricle; coordinates: 1.7 mm lateral, 0.5 mm anterior, 2.0 mm deep; doses based on concentration of hemoglobin found in blood (∼140 mg/mL) and the amount of iron in hemoglobin |
Development of an acute obstructive hydrocephalus model in rats using N-butyl cyanoacrylate | Yong Sook Park & Seung Won Park & Jong Sik Suk & Taik Kyun Nam | 2011 | Rat | Sprague-Dawley | N-Butyl-Cyanoacrylate | Subarachnoid Space | 20 uL of a mixture of NBCA and ethiodized oil. The volume ratio of NBCA to Lipiodol was 4:1. |
280-300 g | Obstructive Hydrocephalus | |
Cerebrospinal fluid absorption disorder of arachnoid villi in a canine model of hydrocephalus | Ke Zhao, Hong Sun, Yan Shan , Bo Yong Mao, Heng Zhang | 2010 | Dog | Mongrel | Silicone Oil | Fourth Ventricle | CSF was drained via the silicone catheters (0.3 ml/kg) and was simultaneously replaced by equivalent amounts of Silicone oil by slow injection (1ml/ min) | 10000-15000 g at 1-2 years | ||
Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats | Ili Slobodian, Dmitri Krassioukov-Enns, and Marc R Del Bigio | 2007 | Rat | Sprague-Dawley | Matrigel® | Cisterna Magna | 35,75,125 μl | 45–55 g at 3 weeks | Obstructive Hydrocephalus | |
Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats | Ili Slobodian, Dmitri Krassioukov-Enns, and Marc R Del Bigio | 2007 | Rat | Sprague-Dawley | Collagen I from rat tail | Cisterna Magna | 30–40 μl | 45–55 g at 3 weeks | Obstructive Hydrocephalus | |
Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats | Ili Slobodian, Dmitri Krassioukov-Enns, and Marc R Del Bigio | 2007 | Rat | Sprague-Dawley | Fibrin Glue (Tisseel®) | Cisterna Magna | 35–55 μl | 45–55 g at 3 weeks | Obstructive Hydrocephalus | |
Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats | Ili Slobodian, Dmitri Krassioukov-Enns, and Marc R Del Bigio | 2007 | Rat | Sprague-Dawley | N-Butyl-Cyanoacrylate | Cisterna Magna | 25–35 μl | 45–55 g at 3 weeks | Obstructive Hydrocephalus | |
Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats | Ili Slobodian, Dmitri Krassioukov-Enns, and Marc R Del Bigio | 2007 | Rat | Sprague-Dawley | Ethylene Vinyl Polymer (Onyx-18 and Onyx-34®) | Cisterna Magna | 35, 25, 15 μl | 45–55 g at 3 weeks | Obstructive Hydrocephalus | |
Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor β1 | Tsuyoshi Tadaa, Hua Zhana, Yuichiro Tanakaa, Kazuhiro Hongoa, Kunio Matsumotob, Toshikazu Nakamurab, | 2006 | Mouse | C57BL/6 | Human Recombinant Transforming Growth Factor β1 | Subcranium | 600 ng/head | 10 PN | Communicating Hydrocephalus |
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