Members

Francesco Mangano, DO,
Mary Jane and Bob Tritsch Professor of Neurological Surgery and Pediatrics Cincinnati Children’s Hospital Medical Center, Division of Pediatric Neurosurgery, University of Cincinnati College of Medicine, Department of Neurological Surgery
Email: francesco.mangano@cchmc.org Lab website: https://www.cincinnatichildrens.org/research/divisions/n/neurosurgery/labs/mangano


Areas of Interest: Biomarkers, CSF Dynamics, Congenital, Developmental Biology, Genetics, Imaging


Research focus:

Research in the Mangano Lab is directed at understanding pathogenesis of pediatric hydrocephalus, that will lead us to develop new surgical and medical treatment options and to improve patient outcomes and quality of life. To establish the goals, we study essential brain anatomy, neural cell types, and genes involved in pediatric hydrocephalus utilizing advanced MR imaging methods (diffusion tensor imaging), mouse genetic models, and several surgical techniques.

Two main aspects of research are currently ongoing in the lab. Each project includes active collaborations with multidisciplinary researchers across divisions at Cincinnati Children’s, including the Division of Radiology, Division of Developmental Biology, and Division of Human Genetics.

Our current projects include:
1.Diffusion tensor imaging and neural stem cell behavior in infantile rat model of obstructive hydrocephalus.
2.Molecular mechanism of non-obstructive pediatric hydrocephalus in mouse genetic mutants.