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September 2021

HANDS Animal Model Webinar Series – Week 2: Adult Animal Models

September 24 @ 12:00 pm - November 22 @ 1:15 am

Date: Friday, September 24th
Time: 12:00 to 1:15 PM EDT

Speakers:

  • Sravanthi Koduri (University of Michigan) – Injection of cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhages (aSAH) into mouse ventricles for hydrocephalus induction
  • Simon Shim (Marshall University) – Rat model with a TMEM67 heterozygous mutation demonstrating hemorrhage at birth and developing late-onset hydrocephalus in adults
  • Margaret Tish (University of Iowa) – Induction of chronic, communicating hydrocephalus in adult mice using kaolin

Register here!

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PCORI Implementation Awards

September 28

Sponsor: Patient-Centered Outcomes Research Institute (PCORI)
LOI Due Date: September 28, 2021 at 5pm ET
Application Due Date: December, 2021 at 5pm ET

Awards:
Limited PCORI Funding Announcement: Implementation of PCORI-Funded Patient-Centered Outcomes Research Results: Up to $1.5 million in total direct costs for Standard Implementation Projects, up to $4.5 million in total direct costs for Phased Implementation Projects, up to $300,000 in total costs for Dissemination Projects.
Implementation of Effective Shared Decision Making Approaches in Practice Settings: $1.5 million
Implementation of Findings from PCORI’s Major Research Investments: Up to $2.5 million

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October 2021

PCORI Engagement Awards

October 1

Sponsor: Patient-Centered Outcomes Research Institute (PCORI)
LOI Due Date: October 1, 2021 at 5pm ET
Application Due Date: January 10, 2022 at 5pm ET

Awards:
Capacity Building: Award total costs may not exceed $250,000 (Direct + Indirect Costs)
Dissemination Initiative: Award total costs may not exceed $250,000 (Direct + Indirect Costs)
Stakeholder Convening Support: Award total costs may not exceed $100,000 (Direct + Indirect Costs)

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PCORI Research Awards

October 5

Sponsor: Patient-Centered Outcomes Research Institute (PCORI)
LOI Due Date: October 5, 2021 at 5pm ET
Application Due Date: January 11, 2022 at 5pm ET

Awards:
Phased Large Awards for Comparative Effectiveness Research: $22 million (Feasibility phase: $2 million; Full-scale study phase: $20 million)
Comparative Effectiveness of Multimodal Interventions to Prevent Osteoporotic Fractures: Up to $10 million
Comparative Effectiveness of Novel Pharmacologic and Evidence-Based Nonpharmacologic Treatments for Migraine Prevention: Up to $10 million
Healthy Aging: Optimizing Physical and Mental Functioning Across the Aging Continuum: Up to $5 million
Broad PCORI Funding Announcements: Addressing Disparities; Assessment of Prevention, Diagnosis, and Treatment Options; and Improving Healthcare Systems: up to $3 million (Small) – up to $5 million (Large) — Communication & Dissemination Research: up to $2 million
Improving Methods for Conducting Patient-Centered Outcomes Research: $750,000

You can register here Virtual Applicant Town Halls for these Funding Announcements

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Comparative Effectiveness of Multimodal Interventions to Prevent Osteoporotic Fractures

October 5

Sponsor: Patient-Centered Outcomes Research Institute (PCORI)
LOI Due Date: October 5, 2021 at 5pm ET
Application Due Date: January 11, 2022 at 5pm ET
Award: Up to $10 million

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HANDS Animal Model Webinar Series – Week 3: Large Animal Models

October 14 @ 2:00 pm - 3:15 pm

(note different day/time)

Date: Thursday, October 14th
Time: 2:00 to 3:15 PM EDT

Speakers:

  • Simon Malpas (University of Auckland) – Development of sheep models for measuring intracranial pressure, blood pressure, and sympathetic activity in conscious animals
  • Pat McAllister (Washington University in St. Louis) – Development of pig models for shunting and third ventriculostomy with choroid plexus cauterization (ETV-CPC)

Register Here!

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NIH R21, R03

October 16
|Recurring Event (See all)

One event on February 16, 2021 at 12:00 am

One event on October 16, 2021 at 12:00 am

Sponsor: National Institute of Health 
DUE DATES: 

  • Cycle 3: October 16, 2020 by 5 PM of local organization time
  • Cycle 1: February 16, 2021 by 5 PM of local organization time
  • Cycle 2: June 16, 2021 by 5 PM of local organization time

Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia: 
The combined budget for direct costs for the two-year project period may not exceed $275,000.  No more than $200,000 may be requested in any single year.
Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed)
The combined budget for direct costs for the two year project period may not exceed $200,000.
Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia (R21)
The combined budget for direct costs for the two-year project period may not exceed $275,000.  No more than $200,000 may be requested in any single year.
Chronic Condition Self-Management in Children and Adolescents (R21 Clinical Trial Optional)
Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year.

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HANDS Animal Model Webinar Series – Week 4: Congenital Genetic Animal Models

October 22 @ 12:00 pm - 1:15 pm

Date: Friday, October 22nd
Time: 12:00 to 1:15 PM EDT

Speakers:

  • Ryan Gray (University of Texas at Austin) – K1F6 mutant mice models demonstrating progressive loss of ependymal cell cilia and hydrocephalus development
  • Bernadette Holdener (Stony Brook University) – B3glct mutant mice models demonstrating development of hydrocephalus and ventriculomegaly

Register Here!

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HANDS Animal Model Webinar Series – Week 5: Posthemorrhagic Animal Models

October 29 @ 12:00 pm - 1:15 pm

Date: Friday, October 29th
Time: 12:00 to 1:15 PM EDT

Speakers:

  • Lauren Jantzie & Dody Robinson (Johns Hopkins Medicine) – Rat model of hydrocephalus via induction of chorioamnionitis (in utero inflammation) and ICV injection of lysed littermate red blood cells postnatally
  • Jennifer Strahle (Washington University School of Medicine in St. Louis) – Mouse model of posthemorrhagic hydrocephalus using the injection of blood products

Register Here!

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November 2021

Clinical Scientist Development Award

November 12

Sponsor: Doris Duke Charitable Foundation
Eligibility Exemption Requests Due: October 15, 2021 at 5 pm ET
Pre-Proposal Applications Due: November 12, 2021 at 3 pm ET
Award: $150,000 annual direct costs plus $15,000 (10%) annual indirect costs for three years

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December 2021

Cycle 1: Alzheimer’s Drug Discovery Foundation

December 3
|Recurring Event (See all)

One event on December 3, 2021 at 12:00 am

LOI Due Dates:

  • Cycle 1: May 28, 2021
  • Cycle 2: October 1, 2021

Full Proposal Deadlines:

  • Cycle 1: July 30, 2021
  • Cycle 2: December 3, 2021

Drug Development Program
The goal of this RFP is to develop therapeutics for Alzheimer’s disease and related dementias. This RFP focuses on building preclinical evidence in animal models and on advancing lead molecules to the clinical candidate selection stage. Average Award: Up to $600,000 based on stage and scope of research.
Program to Accelerate Clinical Trials (PACT)
The goal of this RFP is to increase the number of innovative pharmacologic interventions tested in clinical studies for Alzheimer’s disease and related dementias. Average Award: Up to $3,000,000 based on stage and scope of research. For studies requiring additional support, co-funding from other funding agencies or investors is encouraged.
Neuroimaging and CSF Biomarker Development Prgram
The aim of this RFP is to develop biomarkers for which there is a clear clinical need in Alzheimer’s disease and related dementias. Average award: Up to $600,000 based on stage and scope of research.
Prevention Beyond the Pipeline
The ADDF seeks to support comparative effectiveness research, prevention clinical trials, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline. Average awards: $50,000-$100,000 for epidemiological analyses, and u to $3,000,000 for clinical trials based on stage and scope of research.

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ANGEL (Advanced Neurotherapeutic Grant of Excellence) Award

December 31

Sponsor: International Rett Syndrome Foundation (IRSF)
Due Date: Applications accepted on a rolling basis
Award: Up to $600,000 over two years. Grant awards must be comprised of very specific programs that are focused on pre-clinical drug discovery and development or clinical testing of therapeutic candidates.

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Rolling Basis: Alzheimer’s Drug Discovery Foundation

December 31

PROPOSALS ACCEPTED ON A ROLLING BASIS
ADDF/NIH
Supports NIA and NINDS grant proposals in NIH format that were scored but not funded, which fall within our mission and research priorities.
Conference Funding
Supports scientific conferences that are relevant to our mission with grants up to $10,000.

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February 2022

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

February 9, 2022
|Recurring Event (See all)

One event on February 9, 2022 at 12:00 am

Sponsor: National Institutes of Health (multiple Institutes)
LOI Due Dates: 30 days before deadline
Due Date: August 10, 2021, February 9, 2022
Award: Application budgets are not limited but must reflect the actual needs of the proposed project. Applicants should rarely exceed up to $500,000 total cost per year for Phase I and up to $1,500,000 total cost per year for the Phase II. The Blueprint Neurotherapeutics Network (BPN) encourages applications from small businesses seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories.

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